{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cannata F"],"funding":["Ministero della Salute","Italian Ministry of Health"],"pagination":["e70089"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12483497"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(7)"],"pubmed_abstract":["<h4>Background</h4>In older adults, obesity is associated with frailty, conditions worsened by age related decline in bone mineral density (BMD) and muscle mass.<h4>Objective</h4>To evaluate whether a 3-month Fibre-Enriched High Carbohydrate (FEHC) diet preserves bone health, reduces inflammation and modulates Wnt signalling in older adults with obesity.<h4>Methods</h4>In this clinical trial, 86 women aged 65-85 years with obesity (BMI ≥ 30 kg/m<sup>2</sup>) undergoing hip arthroplasty were assigned to a free control diet (FCD) or a FEHC diet (FEHC) group for 3 months before surgery. Clinical, systemic, and molecular assessments were performed, including gene expression analyses in bone and muscle tissues.<h4>Results</h4>A significant reduction in waist circumference was observed over time"],"journal":["Diabetes/metabolism research and reviews"],"pubmed_title":["Fibre-Enriched High-Carbohydrate (FEHC) Diet Modulates Inflammation Without Affecting Bone Health in Older Women With Obesity: A Randomised Clinical Trial."],"pmcid":["PMC12483497"],"funding_grant_id":["CO-2016-02362346"],"pubmed_authors":["Maccarrone M","Russo F","Faraj M","Papalia R","Banfi G","Tramontana F","Vadala G","Lombardi G","Strollo R","Leanza G","Piccoli A","Sansoni V","Laudisio A","Viola V","Verdelli C","Napoli N","Cannata F"],"additional_accession":[]},"is_claimable":false,"name":"Fibre-Enriched High-Carbohydrate (FEHC) Diet Modulates Inflammation Without Affecting Bone Health in Older Women With Obesity: A Randomised Clinical Trial.","description":"<h4>Background</h4>In older adults, obesity is associated with frailty, conditions worsened by age related decline in bone mineral density (BMD) and muscle mass.<h4>Objective</h4>To evaluate whether a 3-month Fibre-Enriched High Carbohydrate (FEHC) diet preserves bone health, reduces inflammation and modulates Wnt signalling in older adults with obesity.<h4>Methods</h4>In this clinical trial, 86 women aged 65-85 years with obesity (BMI ≥ 30 kg/m<sup>2</sup>) undergoing hip arthroplasty were assigned to a free control diet (FCD) or a FEHC diet (FEHC) group for 3 months before surgery. Clinical, systemic, and molecular assessments were performed, including gene expression analyses in bone and muscle tissues.<h4>Results</h4>A significant reduction in waist circumference was observed over time","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T00:35:59.961Z","creation":"2026-05-03T03:12:25.798Z"},"accession":"S-EPMC12483497","cross_references":{"pubmed":["41026958"],"doi":["10.1002/dmrr.70089"]}}