biostudies-literatureCannata FMinistero della SaluteItalian Ministry of Healthe70089https://www.ebi.ac.uk/biostudies/studies/S-EPMC12483497biostudies-literatureUnknown41(7)<h4>Background</h4>In older adults, obesity is associated with frailty, conditions worsened by age related decline in bone mineral density (BMD) and muscle mass.<h4>Objective</h4>To evaluate whether a 3-month Fibre-Enriched High Carbohydrate (FEHC) diet preserves bone health, reduces inflammation and modulates Wnt signalling in older adults with obesity.<h4>Methods</h4>In this clinical trial, 86 women aged 65-85 years with obesity (BMI ≥ 30 kg/m²) undergoing hip arthroplasty were assigned to a free control diet (FCD) or a FEHC diet (FEHC) group for 3 months before surgery. Clinical, systemic, and molecular assessments were performed, including gene expression analyses in bone and muscle tissues.<h4>Results</h4>A significant reduction in waist circumference was observed over timeDiabetes/metabolism research and reviewsFibre-Enriched High-Carbohydrate (FEHC) Diet Modulates Inflammation Without Affecting Bone Health in Older Women With Obesity: A Randomised Clinical Trial.PMC12483497CO-2016-02362346Maccarrone MRusso FFaraj MPapalia RBanfi GTramontana FVadala GLombardi GStrollo RLeanza GPiccoli ASansoni VLaudisio AViola VVerdelli CNapoli NCannata FfalseFibre-Enriched High-Carbohydrate (FEHC) Diet Modulates Inflammation Without Affecting Bone Health in Older Women With Obesity: A Randomised Clinical Trial.<h4>Background</h4>In older adults, obesity is associated with frailty, conditions worsened by age related decline in bone mineral density (BMD) and muscle mass.<h4>Objective</h4>To evaluate whether a 3-month Fibre-Enriched High Carbohydrate (FEHC) diet preserves bone health, reduces inflammation and modulates Wnt signalling in older adults with obesity.<h4>Methods</h4>In this clinical trial, 86 women aged 65-85 years with obesity (BMI ≥ 30 kg/m²) undergoing hip arthroplasty were assigned to a free control diet (FCD) or a FEHC diet (FEHC) group for 3 months before surgery. Clinical, systemic, and molecular assessments were performed, including gene expression analyses in bone and muscle tissues.<h4>Results</h4>A significant reduction in waist circumference was observed over time2025-01-01T00:00:00Z2025 Oct2026-06-04T00:35:59.961Z2026-05-03T03:12:25.798ZS-EPMC124834974102695810.1002/dmrr.70089