{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28(10)"],"submitter":["Zhang T"],"funding":["Harbin Institute of Technology"],"pubmed_abstract":["<i>Drosophila melanogaster</i> relies on complex brain circuits and neuromodulation for experience-dependent sexual behavior, yet the role of neuropeptide signaling in behavioral refinement remains unclear. We investigate SIFamide (SIFa) and its receptor (SIFaR) in regulating male <i>Drosophila</i> sexual behavior. SIFaR is essential for these behaviors, particularly interval timing. Knockdown in fru-positive neurons impairs courtship index (CI) and mating duration (MD) but not copulation latency (CL). Critically, SIFaR in GABAergic mAL neurons (fru<sup>+</sup>, dsx<sup>-</sup>) specifically controls MD and CI, not CL. Additionally, SIFa signaling in mAL neurons of experienced males increases presynaptic terminals, indicating context-dependent synaptic plasticity. These results reveal a co"],"journal":["iScience"],"pagination":["113516"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12483593"],"repository":["biostudies-literature"],"pubmed_title":["SIFamide-dependent synaptic plasticity in male-specific GABAergic neurons underlies experience-modulated mating behaviors."],"pmcid":["PMC12483593"],"pubmed_authors":["Wu Z","Kim WJ","Zhang T","Miao H","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"SIFamide-dependent synaptic plasticity in male-specific GABAergic neurons underlies experience-modulated mating behaviors.","description":"<i>Drosophila melanogaster</i> relies on complex brain circuits and neuromodulation for experience-dependent sexual behavior, yet the role of neuropeptide signaling in behavioral refinement remains unclear. We investigate SIFamide (SIFa) and its receptor (SIFaR) in regulating male <i>Drosophila</i> sexual behavior. SIFaR is essential for these behaviors, particularly interval timing. Knockdown in fru-positive neurons impairs courtship index (CI) and mating duration (MD) but not copulation latency (CL). Critically, SIFaR in GABAergic mAL neurons (fru<sup>+</sup>, dsx<sup>-</sup>) specifically controls MD and CI, not CL. Additionally, SIFa signaling in mAL neurons of experienced males increases presynaptic terminals, indicating context-dependent synaptic plasticity. These results reveal a co","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-07-15T06:03:47.105Z","creation":"2026-06-30T03:20:16.962Z"},"accession":"S-EPMC12483593","cross_references":{"pubmed":["41035691"],"doi":["10.1016/j.isci.2025.113516"]}}