{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Zhu S"],"pubmed_abstract":["<h4>Background</h4><i>Salmonella</i> Enteritidis (<i>S</i>. Enteritidis) is an important zoonotic pathogen that poses a major threat to animals and human health. TrxB, as a key component of the thioredoxin system, is a thioredoxin reductase ubiquitously present in organisms. It is mainly involved in maintaining cellular redox balance, but its role in the pathogenicity of <i>S</i>. Enteritidis remains unclear.<h4>Methods</h4>In this study, we generated a <i>trxB</i>-deficient strain from <i>S</i>. Enteritidis C50336 strain to investigate how TrxB affects the biological characteristics and pathogenesis of the bacterium. The virulence of Δ<i>trxB</i> was assessed by measuring Δ<i>trxB</i> resistance to environmental stress, biofilm formation ability, motility, adhesion, invasion ability, intr"],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["1659729"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12484166"],"repository":["biostudies-literature"],"pubmed_title":["Characterization and immunoprotection of thioredoxin reductase TrxB knockout mutant of &lt;i&gt;Salmonella&lt;/i&gt; Enteritidis."],"pmcid":["PMC12484166"],"pubmed_authors":["Liu X","Li H","Li C","Dong Y","Zhang Z","Shi Q","Zhu X","Ren C","Zhu S","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Characterization and immunoprotection of thioredoxin reductase TrxB knockout mutant of &lt;i&gt;Salmonella&lt;/i&gt; Enteritidis.","description":"<h4>Background</h4><i>Salmonella</i> Enteritidis (<i>S</i>. Enteritidis) is an important zoonotic pathogen that poses a major threat to animals and human health. TrxB, as a key component of the thioredoxin system, is a thioredoxin reductase ubiquitously present in organisms. It is mainly involved in maintaining cellular redox balance, but its role in the pathogenicity of <i>S</i>. Enteritidis remains unclear.<h4>Methods</h4>In this study, we generated a <i>trxB</i>-deficient strain from <i>S</i>. Enteritidis C50336 strain to investigate how TrxB affects the biological characteristics and pathogenesis of the bacterium. The virulence of Δ<i>trxB</i> was assessed by measuring Δ<i>trxB</i> resistance to environmental stress, biofilm formation ability, motility, adhesion, invasion ability, intr","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-04T02:30:03.431Z","creation":"2026-05-04T03:13:43.972Z"},"accession":"S-EPMC12484166","cross_references":{"pubmed":["41040986"],"doi":["10.3389/fcimb.2025.1659729"]}}