{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zang HJ"],"funding":["the Yunnan Provincial Science and Technology Department","Yunnan Characteristic Plant Screening and R&D Service CXO Platform","Key Research and Development Project of Yunnan Province","YATAS","the National Natural Science Foundation of China"],"pagination":["67"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12484522"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Parkinson's disease (PD), the second most common neurodegenerative disorder globally, arises from selective dopaminergic neuron degeneration. While current therapies address symptoms, disease-modifying agents remain an unmet need. Herein, we investigated Nicotiana tabacum L. (Solanaceae), a plant linked epidemiologically to reduced PD risk, as a source of multi-target neuroprotective compounds. From ultra-low nicotine (< 0.04%) tobacco leaves, we isolated 22 molecules, including a novel 21-norsesterterpenoid (Nicotiazanorpenoid A) and eight previously unreported compounds. Systematic evaluation revealed three synergistic neuroprotective mechanisms: (1) Antioxidant activity: Scopoletin (3) and isoferulic acid (6) showed significant radical scavenging capacity (ABTS assay; IC<sub>50</sub> = "],"journal":["Natural products and bioprospecting"],"pubmed_title":["Neuroprotective effects of chemical constituents from Nicotiana tabacum L. in Parkinson's disease."],"pmcid":["PMC12484522"],"funding_grant_id":["202201AS070040","202203AC100009","202003AD150012","202302AA310035","82293683","2022530000241012","2022YKZY001"],"pubmed_authors":["Yin QY","Zang HJ","Wang YC","Liao X","Di YT","Sui XY","Hao XJ","Zhai XR","Bai XL","Wang YH","Xin ZQ"],"additional_accession":[]},"is_claimable":false,"name":"Neuroprotective effects of chemical constituents from Nicotiana tabacum L. in Parkinson's disease.","description":"Parkinson's disease (PD), the second most common neurodegenerative disorder globally, arises from selective dopaminergic neuron degeneration. While current therapies address symptoms, disease-modifying agents remain an unmet need. Herein, we investigated Nicotiana tabacum L. (Solanaceae), a plant linked epidemiologically to reduced PD risk, as a source of multi-target neuroprotective compounds. From ultra-low nicotine (< 0.04%) tobacco leaves, we isolated 22 molecules, including a novel 21-norsesterterpenoid (Nicotiazanorpenoid A) and eight previously unreported compounds. Systematic evaluation revealed three synergistic neuroprotective mechanisms: (1) Antioxidant activity: Scopoletin (3) and isoferulic acid (6) showed significant radical scavenging capacity (ABTS assay; IC<sub>50</sub> = ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T00:36:21.167Z","creation":"2026-05-03T03:12:30.3Z"},"accession":"S-EPMC12484522","cross_references":{"pubmed":["41028298"],"doi":["10.1007/s13659-025-00541-8"]}}