{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Noke Durden W"],"funding":["John H. Prescott Marine Mammal Rescue, Assistance Grant, SeaWorld Busch Gardens Conservation Fund, Discover Florida Ocean’s License Plate, Brevard County Tourism and Development Council","Herbert W. Hoover Foundation"],"pubmed_abstract":["Climate warming is one factor increasing the severity of harmful algal blooms (HABs). Innovative exposure models are needed to understand how HABs affect brain health. Here, we examined HAB exposure on the brain transcriptome of dolphins found stranded in Florida's Indian River Lagoon. We report the neurotoxin 2,4-diaminobutyric acid (2,4-DAB) is 2900 times more concentrated in dolphin brains during bloom seasons compared to non-bloom seasons. The same dolphins show 536 differentially expressed genes whose enrichment reveal impairment in GABAergic synapses, basement membrane alteration, and Alzheimer's disease (AD) risk factors that increase with each subsequent season. Dolphins also display concurrent AD-like neuropathological changes and elevated AD gene expression with 2,4-DAB exposure."],"journal":["Communications biology"],"pagination":["1400"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12484975"],"repository":["biostudies-literature"],"pubmed_title":["Alzheimer's disease signatures in the brain transcriptome of Estuarine Dolphins."],"pmcid":["PMC12484975"],"pubmed_authors":["Cox PA","Brand LE","Vontell RT","Garamszegi SP","Banack SA","Brzostowicki DJ","Noke Durden W","Stolen MK","Davis DA"],"additional_accession":[]},"is_claimable":false,"name":"Alzheimer's disease signatures in the brain transcriptome of Estuarine Dolphins.","description":"Climate warming is one factor increasing the severity of harmful algal blooms (HABs). Innovative exposure models are needed to understand how HABs affect brain health. Here, we examined HAB exposure on the brain transcriptome of dolphins found stranded in Florida's Indian River Lagoon. We report the neurotoxin 2,4-diaminobutyric acid (2,4-DAB) is 2900 times more concentrated in dolphin brains during bloom seasons compared to non-bloom seasons. The same dolphins show 536 differentially expressed genes whose enrichment reveal impairment in GABAergic synapses, basement membrane alteration, and Alzheimer's disease (AD) risk factors that increase with each subsequent season. Dolphins also display concurrent AD-like neuropathological changes and elevated AD gene expression with 2,4-DAB exposure.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-04T16:32:29.824Z","creation":"2026-05-13T14:24:30.219Z"},"accession":"S-EPMC12484975","cross_references":{"pubmed":["41028277"],"doi":["10.1038/s42003-025-08796-0"]}}