{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tao X"],"funding":["National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["66"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12485191"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Dental pulp-dentin complex defects remain a major unresolved problem in oral medicines. Clinical therapeutic methods including root canal therapy and vital pulp therapy are both considered as conservative strategies, which are incapable of repairing the pulp-dentin complex defects. Although biomaterial-based strategies show remarkable progress in antibacterial, anti-inflammatory, and pulp regeneration, the important modulatory effects of nerves within pulp cavity have been greatly overlooked, making it challenging to achieve functional pulp-dentin complex regeneration. In this study, we propose an injectable bioceramics-containing composite hydrogel in combination of Li-Ca-Si (LCS) bioceramics and gelatin methacrylate matrix with photo-crosslinking properties. Due to the sustained release "],"journal":["International journal of oral science"],"pubmed_title":["An injectable bioceramics-containing composite hydrogel promoting innervation for pulp-dentin complex repair."],"pmcid":["PMC12485191"],"funding_grant_id":["52272284,32225028"],"pubmed_authors":["Huang J","Tao X","Zhang H","Wu C","Fang B","Mei P","Huan Z"],"additional_accession":[]},"is_claimable":false,"name":"An injectable bioceramics-containing composite hydrogel promoting innervation for pulp-dentin complex repair.","description":"Dental pulp-dentin complex defects remain a major unresolved problem in oral medicines. Clinical therapeutic methods including root canal therapy and vital pulp therapy are both considered as conservative strategies, which are incapable of repairing the pulp-dentin complex defects. Although biomaterial-based strategies show remarkable progress in antibacterial, anti-inflammatory, and pulp regeneration, the important modulatory effects of nerves within pulp cavity have been greatly overlooked, making it challenging to achieve functional pulp-dentin complex regeneration. In this study, we propose an injectable bioceramics-containing composite hydrogel in combination of Li-Ca-Si (LCS) bioceramics and gelatin methacrylate matrix with photo-crosslinking properties. Due to the sustained release ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T01:55:53.444Z","creation":"2026-05-04T03:14:14.936Z"},"accession":"S-EPMC12485191","cross_references":{"pubmed":["41027854"],"doi":["10.1038/s41368-025-00398-0"]}}