biostudies-literatureTao XNational Natural Science Foundation of China (National Science Foundation of China)66https://www.ebi.ac.uk/biostudies/studies/S-EPMC12485191biostudies-literatureUnknown17(1)Dental pulp-dentin complex defects remain a major unresolved problem in oral medicines. Clinical therapeutic methods including root canal therapy and vital pulp therapy are both considered as conservative strategies, which are incapable of repairing the pulp-dentin complex defects. Although biomaterial-based strategies show remarkable progress in antibacterial, anti-inflammatory, and pulp regeneration, the important modulatory effects of nerves within pulp cavity have been greatly overlooked, making it challenging to achieve functional pulp-dentin complex regeneration. In this study, we propose an injectable bioceramics-containing composite hydrogel in combination of Li-Ca-Si (LCS) bioceramics and gelatin methacrylate matrix with photo-crosslinking properties. Due to the sustained release International journal of oral scienceAn injectable bioceramics-containing composite hydrogel promoting innervation for pulp-dentin complex repair.PMC1248519152272284,32225028Huang JTao XZhang HWu CFang BMei PHuan ZfalseAn injectable bioceramics-containing composite hydrogel promoting innervation for pulp-dentin complex repair.Dental pulp-dentin complex defects remain a major unresolved problem in oral medicines. Clinical therapeutic methods including root canal therapy and vital pulp therapy are both considered as conservative strategies, which are incapable of repairing the pulp-dentin complex defects. Although biomaterial-based strategies show remarkable progress in antibacterial, anti-inflammatory, and pulp regeneration, the important modulatory effects of nerves within pulp cavity have been greatly overlooked, making it challenging to achieve functional pulp-dentin complex regeneration. In this study, we propose an injectable bioceramics-containing composite hydrogel in combination of Li-Ca-Si (LCS) bioceramics and gelatin methacrylate matrix with photo-crosslinking properties. Due to the sustained release 2025-01-01T00:00:00Z2025 Oct2026-06-04T01:55:53.444Z2026-05-04T03:14:14.936ZS-EPMC124851914102785410.1038/s41368-025-00398-0