{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(9)"],"submitter":["Cao B"],"pubmed_abstract":["DNA storage provides a high storage density and durability, but current systems experience high latency and lack data security. This study proposed the use of frequency dictionary mapping coding (FDMC) to enable handle-level random access of DNA archival storage. In addition, a hybrid e-molecular encryption strategy and a multi-level error-correction algorithm were introduced to ensure data security and integrity. The simulation and wet experiment results demonstrated that FDMC achieved handle-level random access in a lossless encrypted DNA storage system, which balanced security and robustness. Even in extreme cases, in which there was a 10% loss of DNA sequences, this system still recovered 91.74% of the original data while ensuring a storage density above 1.80 bits per nucleotide. In su"],"journal":["Patterns (New York, N.Y.)"],"pagination":["101288"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12485530"],"repository":["biostudies-literature"],"pubmed_title":["Achieving handle-level random access in an encrypted DNA archival storage system via frequency dictionary mapping coding."],"pmcid":["PMC12485530"],"pubmed_authors":["Li X","Zheng Y","He T","Wang B","Zhang X","Cao B","Zhang Q"],"additional_accession":[]},"is_claimable":false,"name":"Achieving handle-level random access in an encrypted DNA archival storage system via frequency dictionary mapping coding.","description":"DNA storage provides a high storage density and durability, but current systems experience high latency and lack data security. This study proposed the use of frequency dictionary mapping coding (FDMC) to enable handle-level random access of DNA archival storage. In addition, a hybrid e-molecular encryption strategy and a multi-level error-correction algorithm were introduced to ensure data security and integrity. The simulation and wet experiment results demonstrated that FDMC achieved handle-level random access in a lossless encrypted DNA storage system, which balanced security and robustness. Even in extreme cases, in which there was a 10% loss of DNA sequences, this system still recovered 91.74% of the original data while ensuring a storage density above 1.80 bits per nucleotide. In su","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-04T02:25:02.191Z","creation":"2026-05-04T03:13:16.281Z"},"accession":"S-EPMC12485530","cross_references":{"pubmed":["41040959"],"doi":["10.1016/j.patter.2025.101288"]}}