{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Morrel J"],"funding":["NIDA NIH HHS","NIEHS NIH HHS","NIMH NIH HHS","NINDS NIH HHS"],"pubmed_abstract":["<h4>Background</h4>Ambient air pollution exposure is associated with structural brain differences and poorer cognition in children; however, mechanisms of toxicity remain unclear. Perivascular spaces (PVS), key for brain waste clearance, may play a role in the neurotoxicity of air pollution. This study explored associations between air pollution exposure, PVS morphology, and cognition in preadolescents.<h4>Methods</h4>We analyzed cross-sectional Adolescent Brain Cognitive Development<sup>SM</sup> (ABCD) Study<sup>®</sup> data from 6,949 9-10-year-old participants. Annual average exposures to PM<sub>2.5</sub>, O<sub>3</sub>, NO<sub>2</sub>, and 15 PM<sub>2.5</sub> components were estimated using spatiotemporal models mapped to residential addresses. PVS count and volume were derived from T1"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.09.26.678867"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12485759"],"repository":["biostudies-literature"],"pubmed_title":["Outdoor Air Pollution, Perivascular Space Morphology, and Cognition in Preadolescence."],"pmcid":["PMC12485759"],"funding_grant_id":["T32 ES013678","U01 DA041117","U24 DA041123","U24 DA041147","U01 DA041174","R01 ES031074","R01 NS128486","U01 DA041156","U01 DA041134","U01 DA041093","RF1 MH123223","P30 ES000002","U01 DA051037","U01 DA041106","U01 DA041028","U01 DA041089","R01 ES032295","U01 DA041022","U01 DA041120","U01 DA041148","U01 DA041048","U01 DA041025","U01 DA051039","U01 DA051038","U01 DA051016","U01 DA051018","U01 DA050988","P30 ES007048","U01 DA050987","U01 DA050989"],"pubmed_authors":["Chen JC","Rosario M","Torgerson C","Sukumaran K","Herting MM","Schwartz J","Choupan J","Lan H","Morrel J"],"additional_accession":[]},"is_claimable":false,"name":"Outdoor Air Pollution, Perivascular Space Morphology, and Cognition in Preadolescence.","description":"<h4>Background</h4>Ambient air pollution exposure is associated with structural brain differences and poorer cognition in children; however, mechanisms of toxicity remain unclear. Perivascular spaces (PVS), key for brain waste clearance, may play a role in the neurotoxicity of air pollution. This study explored associations between air pollution exposure, PVS morphology, and cognition in preadolescents.<h4>Methods</h4>We analyzed cross-sectional Adolescent Brain Cognitive Development<sup>SM</sup> (ABCD) Study<sup>®</sup> data from 6,949 9-10-year-old participants. Annual average exposures to PM<sub>2.5</sub>, O<sub>3</sub>, NO<sub>2</sub>, and 15 PM<sub>2.5</sub> components were estimated using spatiotemporal models mapped to residential addresses. PVS count and volume were derived from T1","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-08T03:20:03.409Z","creation":"2026-05-08T03:10:50.488Z"},"accession":"S-EPMC12485759","cross_references":{"pubmed":["41040249"],"doi":["10.1101/2025.09.26.678867"]}}