{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ishimatsu M"],"funding":["Lotte Research Promotion Grant","Uehara Memorial Foundation","Support for Pioneering Research Initiated by the Next Generation","Japan Society for the Promotion of Science"],"pagination":["1643-1657"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12485865"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(10)"],"pubmed_abstract":["Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a master transcriptional cofactor for mitochondrial biogenesis. Mitochondrial intermediate peptidase (MIPEP), a mitochondrial signal peptidase, plays an important role in the maturation and activation of mitochondrial proteins. Caloric restriction has lifespan-extending effects that are reportedly exerted through induced expression of PGC-1α and MIPEP in white adipose tissue. To evaluate how upregulation of PGC-1α and MIPEP contributes to changes in the cellular characteristics of adipocytes, this study examined the mitochondrial function and differentiation of 3T3-L1 preadipocytes with single overexpression (OE) or double OE of Pgc-1α and Mipep. Compared with single-OE cells, double-OE cells exhibited no sign"],"journal":["FEBS open bio"],"pubmed_title":["Co-overexpression of the caloric restriction-induced mitochondrial factors PGC-1α and MIPEP upregulates Phospho1 expression in adipocytes."],"pmcid":["PMC12485865"],"funding_grant_id":["20K1","JPMJSP215","17K1323"],"pubmed_authors":["Higami Y","Kato K","Mizunoe Y","Narita T","Taki K","Ishimatsu M","Nozaki Y","Hayami A","Kobayashi M","Mori R"],"additional_accession":[]},"is_claimable":false,"name":"Co-overexpression of the caloric restriction-induced mitochondrial factors PGC-1α and MIPEP upregulates Phospho1 expression in adipocytes.","description":"Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a master transcriptional cofactor for mitochondrial biogenesis. Mitochondrial intermediate peptidase (MIPEP), a mitochondrial signal peptidase, plays an important role in the maturation and activation of mitochondrial proteins. Caloric restriction has lifespan-extending effects that are reportedly exerted through induced expression of PGC-1α and MIPEP in white adipose tissue. To evaluate how upregulation of PGC-1α and MIPEP contributes to changes in the cellular characteristics of adipocytes, this study examined the mitochondrial function and differentiation of 3T3-L1 preadipocytes with single overexpression (OE) or double OE of Pgc-1α and Mipep. Compared with single-OE cells, double-OE cells exhibited no sign","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T00:33:35.265Z","creation":"2026-05-03T03:11:51.872Z"},"accession":"S-EPMC12485865","cross_references":{"pubmed":["40574346"],"doi":["10.1002/2211-5463.70077"]}}