{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(42)"],"submitter":["Lee J"],"pubmed_abstract":["The chemical roles of lanthanides in biology are increasingly recognized, yet remain largely unexplored. Unlike most lanthanides, cerium is redox-active and readily adapted for chemical transformation. Herein, we report a cerium-mediated oxidative thiol-ene coupling between cysteine-derived thiols and styrenes under aqueous conditions, yielding β-hydroxysulfide products. Building on this reactivity, we developed a site-selective cysteine modification strategy using a 17-amino acid cerium-binding sequence. Only cysteines optimally positioned near the vacant coordination site undergo efficient and rapid labeling, particularly with electron-deficient styrene derivatives. This work demonstrates cerium-mediated biological activity and highlights its potential as a reactive center for site-selective bioconjugation and broader biochemical and synthetic applications."],"journal":["Chemical science"],"pagination":["19658-19668"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12486149"],"repository":["biostudies-literature"],"pubmed_title":["Cerium-mediated site-selective cysteine functionalization."],"pmcid":["PMC12486149"],"pubmed_authors":["Song WJ","Lee J"],"additional_accession":[]},"is_claimable":false,"name":"Cerium-mediated site-selective cysteine functionalization.","description":"The chemical roles of lanthanides in biology are increasingly recognized, yet remain largely unexplored. Unlike most lanthanides, cerium is redox-active and readily adapted for chemical transformation. Herein, we report a cerium-mediated oxidative thiol-ene coupling between cysteine-derived thiols and styrenes under aqueous conditions, yielding β-hydroxysulfide products. Building on this reactivity, we developed a site-selective cysteine modification strategy using a 17-amino acid cerium-binding sequence. Only cysteines optimally positioned near the vacant coordination site undergo efficient and rapid labeling, particularly with electron-deficient styrene derivatives. This work demonstrates cerium-mediated biological activity and highlights its potential as a reactive center for site-selective bioconjugation and broader biochemical and synthetic applications.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-05T09:21:48.502Z","creation":"2026-05-15T03:12:49.934Z"},"accession":"S-EPMC12486149","cross_references":{"pubmed":["41041124"],"doi":["10.1039/d5sc04538j"]}}