{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lu Q"],"funding":["NIDDK NIH HHS","NIH HHS"],"pagination":["eadk2536"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12486176"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["385(6716)"],"pubmed_abstract":["Harnessing the microbiome to benefit human health requires an initial step in determining the identity and function of causative microorganisms that affect specific host physiological functions. We show a functional screen of the bacterial microbiota from mice with low intestinal immunoglobulin A (IgA) levels; we identified a Gram-negative bacterium, proposed as <i>Tomasiella immunophila</i>, that induces and degrades IgA in the mouse intestine. Mice harboring <i>T. immunophila</i> are susceptible to infections and show poor mucosal repair. <i>T. immunophila</i> is auxotrophic for the bacterial cell wall amino sugar N-acetylmuramic acid. It delivers immunoglobulin-degrading proteases into outer membrane vesicles that preferentially degrade rodent antibodies with kappa but not lambda light chains. This work indicates a role for symbionts in immunodeficiency, which might be applicable to human disease."],"journal":["Science (New York, N.Y.)"],"pubmed_title":["A host-adapted auxotrophic gut symbiont induces mucosal immunodeficiency."],"pmcid":["PMC12486176"],"funding_grant_id":["F32 DK136180","S10 OD023436"],"pubmed_authors":["Zhou JY","Stappenbeck TS","Sangwan N","Han Y","Nolan LS","Hitch TCA","Karell PE","Baldridge MT","Espenschied ST","Salazar V","Newhall KP","Lawrence D","Dwidar M","Clavel T","Lu Q"],"additional_accession":[]},"is_claimable":false,"name":"A host-adapted auxotrophic gut symbiont induces mucosal immunodeficiency.","description":"Harnessing the microbiome to benefit human health requires an initial step in determining the identity and function of causative microorganisms that affect specific host physiological functions. We show a functional screen of the bacterial microbiota from mice with low intestinal immunoglobulin A (IgA) levels; we identified a Gram-negative bacterium, proposed as <i>Tomasiella immunophila</i>, that induces and degrades IgA in the mouse intestine. Mice harboring <i>T. immunophila</i> are susceptible to infections and show poor mucosal repair. <i>T. immunophila</i> is auxotrophic for the bacterial cell wall amino sugar N-acetylmuramic acid. It delivers immunoglobulin-degrading proteases into outer membrane vesicles that preferentially degrade rodent antibodies with kappa but not lambda light chains. This work indicates a role for symbionts in immunodeficiency, which might be applicable to human disease.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-06-04T00:36:38.504Z","creation":"2026-05-03T03:12:33.69Z"},"accession":"S-EPMC12486176","cross_references":{"pubmed":["39325906"],"doi":["10.1126/science.adk2536"]}}