{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Harada N"],"funding":["Takeda Science Foundation","Japan Agency for Medical Research and Development","Hoansha Foundation","Japan Science and Technology Agency","Japan Society for the Promotion of Science"],"pagination":["e71286"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12486328"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(19)"],"pubmed_abstract":["<h4>Background</h4>We have previously developed a gold nanoparticle (GNP)-based anti-cancer immunotherapy, termed integrated glyco-nanovaccine (iGN). The iGN is composed of GNPs conjugated to a synthetic toll-like receptor (TLR) 7 ligand, an antigen peptide, and a mannose sugar chain. However, the effect of the combination of different sugar chains and antigen peptides on iGN-mediated anticancer immunotherapy remains to be elucidated.<h4>Objective</h4>We compared the anti-tumor effects of two different sugar chains: α-mannose and sialic acid.<h4>Results</h4>We showed that not only the sugar chain but also the antigen peptide plays a pivotal role in iGN uptake by immune cells. In contrast to α-mannose, which promoted GNP internalization by bone marrow-derived dendritic cells (BMDC), sialic "],"journal":["Cancer medicine"],"pubmed_title":["Peptide Modulation Overrides Glycan Synergy in Gold Nanoparticle-Based Vaccines for Cancer Immunotherapy."],"pmcid":["PMC12486328"],"funding_grant_id":["JPMJFR226J","JP22cm0106382","24H00864","24H00865","JPMJPR17HA","JP22gm6210030"],"pubmed_authors":["Sakamoto Y","Wada S","Moroishi T","Shimoda M","Shinchi H","Murata K","Wakao M","Niimura M","Harada N","Kamba T","Nita A"],"additional_accession":[]},"is_claimable":false,"name":"Peptide Modulation Overrides Glycan Synergy in Gold Nanoparticle-Based Vaccines for Cancer Immunotherapy.","description":"<h4>Background</h4>We have previously developed a gold nanoparticle (GNP)-based anti-cancer immunotherapy, termed integrated glyco-nanovaccine (iGN). The iGN is composed of GNPs conjugated to a synthetic toll-like receptor (TLR) 7 ligand, an antigen peptide, and a mannose sugar chain. However, the effect of the combination of different sugar chains and antigen peptides on iGN-mediated anticancer immunotherapy remains to be elucidated.<h4>Objective</h4>We compared the anti-tumor effects of two different sugar chains: α-mannose and sialic acid.<h4>Results</h4>We showed that not only the sugar chain but also the antigen peptide plays a pivotal role in iGN uptake by immune cells. In contrast to α-mannose, which promoted GNP internalization by bone marrow-derived dendritic cells (BMDC), sialic ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T01:26:51.527Z","creation":"2026-05-03T03:14:11.285Z"},"accession":"S-EPMC12486328","cross_references":{"pubmed":["41031725"],"doi":["10.1002/cam4.71286"]}}