{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lai J"],"funding":["the project of Administration of Traditional Chinese Medicine of Zhejiang province"],"pagination":["405"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12486672"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["<h4>Background</h4>Autoimmune nodopathy is a distinct entity characterized by antibodies targeting nodal/paranodal proteins like neurofascin-186 (NF186), leading to conduction defects and neurological dysfunction. This report highlights a unique case of autoimmune nodopathy with anti-NF186 antibodies following SARS-CoV-2 infection.<h4>Case presentation</h4>A 47-year-old female developed acute limb numbness and weakness ten days post-COVID-19 diagnosis, which progressed to respiratory muscle paralysis necessitating mechanical ventilation. Initial treatments with intravenous immunoglobulin and steroids were ineffective. Diagnosis of autoimmune nodopathy with anti-NF186 antibodies was confirmed through clinical examination, electromyography (EMG), and serum antibody testing using cell-based a"],"journal":["BMC neurology"],"pubmed_title":["Autoimmune nodopathy with anti-NF186 antibodies following SARS-CoV-2 infection: a case report."],"pmcid":["PMC12486672"],"funding_grant_id":["2021ZB019"],"pubmed_authors":["Lai J","Zhang X","Wang H","Zhu W","Wang Y","Cheng Y"],"additional_accession":[]},"is_claimable":false,"name":"Autoimmune nodopathy with anti-NF186 antibodies following SARS-CoV-2 infection: a case report.","description":"<h4>Background</h4>Autoimmune nodopathy is a distinct entity characterized by antibodies targeting nodal/paranodal proteins like neurofascin-186 (NF186), leading to conduction defects and neurological dysfunction. This report highlights a unique case of autoimmune nodopathy with anti-NF186 antibodies following SARS-CoV-2 infection.<h4>Case presentation</h4>A 47-year-old female developed acute limb numbness and weakness ten days post-COVID-19 diagnosis, which progressed to respiratory muscle paralysis necessitating mechanical ventilation. Initial treatments with intravenous immunoglobulin and steroids were ineffective. Diagnosis of autoimmune nodopathy with anti-NF186 antibodies was confirmed through clinical examination, electromyography (EMG), and serum antibody testing using cell-based a","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-03T03:20:32.851Z","creation":"2026-05-03T03:13:05.72Z"},"accession":"S-EPMC12486672","cross_references":{"pubmed":["41029496"],"doi":["10.1186/s12883-025-04417-9"]}}