biostudies-literatureLai Jthe project of Administration of Traditional Chinese Medicine of Zhejiang province405https://www.ebi.ac.uk/biostudies/studies/S-EPMC12486672biostudies-literatureUnknown25(1)<h4>Background</h4>Autoimmune nodopathy is a distinct entity characterized by antibodies targeting nodal/paranodal proteins like neurofascin-186 (NF186), leading to conduction defects and neurological dysfunction. This report highlights a unique case of autoimmune nodopathy with anti-NF186 antibodies following SARS-CoV-2 infection.<h4>Case presentation</h4>A 47-year-old female developed acute limb numbness and weakness ten days post-COVID-19 diagnosis, which progressed to respiratory muscle paralysis necessitating mechanical ventilation. Initial treatments with intravenous immunoglobulin and steroids were ineffective. Diagnosis of autoimmune nodopathy with anti-NF186 antibodies was confirmed through clinical examination, electromyography (EMG), and serum antibody testing using cell-based aBMC neurologyAutoimmune nodopathy with anti-NF186 antibodies following SARS-CoV-2 infection: a case report.PMC124866722021ZB019Lai JZhang XWang HZhu WWang YCheng YfalseAutoimmune nodopathy with anti-NF186 antibodies following SARS-CoV-2 infection: a case report.<h4>Background</h4>Autoimmune nodopathy is a distinct entity characterized by antibodies targeting nodal/paranodal proteins like neurofascin-186 (NF186), leading to conduction defects and neurological dysfunction. This report highlights a unique case of autoimmune nodopathy with anti-NF186 antibodies following SARS-CoV-2 infection.<h4>Case presentation</h4>A 47-year-old female developed acute limb numbness and weakness ten days post-COVID-19 diagnosis, which progressed to respiratory muscle paralysis necessitating mechanical ventilation. Initial treatments with intravenous immunoglobulin and steroids were ineffective. Diagnosis of autoimmune nodopathy with anti-NF186 antibodies was confirmed through clinical examination, electromyography (EMG), and serum antibody testing using cell-based a2025-01-01T00:00:00Z2025 Sep2026-05-03T03:20:32.851Z2026-05-03T03:13:05.72ZS-EPMC124866724102949610.1186/s12883-025-04417-9