biostudies-literatureFeng Zthe Guangdong Basic and Applied Basic Research Foundationthe Plan on Enhancing Scientific Research in GMUthe National Natural Science Foundation of China988https://www.ebi.ac.uk/biostudies/studies/S-EPMC12486792biostudies-literatureUnknown25(1)<h4>Background</h4>Hypertensive disorders of pregnancy (HDP) significantly impact infant outcomes. However, evidence regarding HDP's effects on twin pregnancies remains limited and poorly characterized. This study aimed to investigate the impact of HDP on perinatal outcomes and neonatal complications in twin pregnancies.<h4>Methods</h4>Data were collected from 22 medical centers across 12 Chinese provinces between January 2018 and December 2020. The primary variable of interest was HDP (including gestational hypertension and preeclampsia). Perinatal outcomes and neonatal complications were systematically assessed using multivariable logistic regression, propensity score matching, and overlap weighting (OW).<h4>Results</h4>Among 6,307 twin pregnancies, 1,013 cases (16.1%) were diagnosed witBMC pregnancy and childbirthThe impact of hypertensive disorders of pregnancy on perinatal outcomes in twin pregnancies: a national multi-center cohort study.PMC1248679282402011GMUCR2025-010032024A1515220100Qiu JLiu JLiu LMeng QJia CJiang HLin XWei XWei YWu FDing YWang YShen WZhang AFeng ZJin YYang CYan WCui QZhang WYang XTong XMHe ZZhang YCai YfalseThe impact of hypertensive disorders of pregnancy on perinatal outcomes in twin pregnancies: a national multi-center cohort study.<h4>Background</h4>Hypertensive disorders of pregnancy (HDP) significantly impact infant outcomes. However, evidence regarding HDP's effects on twin pregnancies remains limited and poorly characterized. This study aimed to investigate the impact of HDP on perinatal outcomes and neonatal complications in twin pregnancies.<h4>Methods</h4>Data were collected from 22 medical centers across 12 Chinese provinces between January 2018 and December 2020. The primary variable of interest was HDP (including gestational hypertension and preeclampsia). Perinatal outcomes and neonatal complications were systematically assessed using multivariable logistic regression, propensity score matching, and overlap weighting (OW).<h4>Results</h4>Among 6,307 twin pregnancies, 1,013 cases (16.1%) were diagnosed wit2025-01-01T00:00:00Z2025 Oct2026-06-04T02:21:09.518Z2026-05-04T03:13:38.19ZS-EPMC124867924103473110.1186/s12884-025-08042-9