{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chan ACY"],"funding":["Ministry of Education - Singapore","National Medical Research Council"],"pagination":["219"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12486793"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["Small fiber neuropathy (SFN) affects small-diameter sensory and autonomic nerve fibers, leading to chronic pain and autonomic dysfunction. While SFN can be associated with diabetes and autoimmune diseases, a significant proportion of cases are idiopathic. Although immune-mediated mechanisms are being recognized increasingly in SFN, their precise role remains unclear. This study investigates the presence of autoantibodies against interferon-induced GTP-binding protein MX (MX1) in SFN patients and explores their potential pathogenic role. A total of 59 patients with skin biopsy-confirmed SFN and 20 healthy controls were recruited. Serum samples were analyzed for the presence of anti-MX1 autoantibodies using enzyme-linked immunosorbent assay (ELISA). Immunohistochemistry was performed on rat "],"journal":["Journal of neuroinflammation"],"pubmed_title":["Interferon-induced GTP-binding protein MX1 drives hyperexcitability in peripheral nerves: a novel mechanism in small fiber neuropathy."],"pmcid":["PMC12486793"],"funding_grant_id":["NUHSRO/2021/059/T1/Seed-Mar/02","MOH-000437-00"],"pubmed_authors":["Sharma VK","Wong HY","Huang H","Teoh HL","Li R","Soong TW","Foo NWJ","Mak A","Chan ACY","Shah A","Mohammad Rizal NAB","Schwarz H","Zhang B"],"additional_accession":[]},"is_claimable":false,"name":"Interferon-induced GTP-binding protein MX1 drives hyperexcitability in peripheral nerves: a novel mechanism in small fiber neuropathy.","description":"Small fiber neuropathy (SFN) affects small-diameter sensory and autonomic nerve fibers, leading to chronic pain and autonomic dysfunction. While SFN can be associated with diabetes and autoimmune diseases, a significant proportion of cases are idiopathic. Although immune-mediated mechanisms are being recognized increasingly in SFN, their precise role remains unclear. This study investigates the presence of autoantibodies against interferon-induced GTP-binding protein MX (MX1) in SFN patients and explores their potential pathogenic role. A total of 59 patients with skin biopsy-confirmed SFN and 20 healthy controls were recruited. Serum samples were analyzed for the presence of anti-MX1 autoantibodies using enzyme-linked immunosorbent assay (ELISA). Immunohistochemistry was performed on rat ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-05T08:45:52.387Z","creation":"2026-05-14T03:12:28.931Z"},"accession":"S-EPMC12486793","cross_references":{"pubmed":["41035025"],"doi":["10.1186/s12974-025-03557-6"]}}