{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(18)"],"submitter":["Fan SS"],"pubmed_abstract":["Autoimmune diseases are driven by a breach of self-tolerance, leading to chronic inflammation and organ damage. While the Th1 and Th17 paradigms have long dominated our understanding of T-cell-mediated pathology, a distinct subset of CD4<sup>+</sup> T helper cells defined by the production of granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a central and non-redundant pathogenic driver. These GM-CSF-producing Th cells orchestrate autoimmune pathology across a spectrum of diseases, including multiple sclerosis, rheumatoid arthritis, and type 1 diabetes, among others. Mechanistically, they act as critical amplifiers of inflammation by activating and recruiting myeloid cells, which in turn mediate tissue destruction. Furthermore, they establish vicious feedback loops, "],"journal":["Theranostics"],"pagination":["9944-9968"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12486991"],"repository":["biostudies-literature"],"pubmed_title":["GM-CSF&lt;sup&gt;+&lt;/sup&gt; Th: a central player in autoimmunity."],"pmcid":["PMC12486991"],"pubmed_authors":["Fan SS","Liu Y","Meng XY","Luo YB","Xu X"],"additional_accession":[]},"is_claimable":false,"name":"GM-CSF&lt;sup&gt;+&lt;/sup&gt; Th: a central player in autoimmunity.","description":"Autoimmune diseases are driven by a breach of self-tolerance, leading to chronic inflammation and organ damage. While the Th1 and Th17 paradigms have long dominated our understanding of T-cell-mediated pathology, a distinct subset of CD4<sup>+</sup> T helper cells defined by the production of granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a central and non-redundant pathogenic driver. These GM-CSF-producing Th cells orchestrate autoimmune pathology across a spectrum of diseases, including multiple sclerosis, rheumatoid arthritis, and type 1 diabetes, among others. Mechanistically, they act as critical amplifiers of inflammation by activating and recruiting myeloid cells, which in turn mediate tissue destruction. Furthermore, they establish vicious feedback loops, ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-07-15T09:47:23.727Z","creation":"2026-07-02T03:12:37.936Z"},"accession":"S-EPMC12486991","cross_references":{"pubmed":["41041077"],"doi":["10.7150/thno.121766"]}}