{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cui X"],"funding":["Natural Science Foundation of Shanxi"],"pagination":["216"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12487243"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["<h4>Background</h4>Premature ovarian failure (POF) is a debilitating condition impairing fertility and health in women. Mesenchymal stem cell-derived exosomes (MSC-EVs) have emerged as a promising therapeutic option for POF due to their regenerative capabilities. This study explores the effectiveness of human umbilical cord mesenchymal stem cell-derived exosomes (HuMSCs-Exos) in counteracting NLRP3-mediated pyroptosis and restoring ovarian function in a cyclophosphamide (CTX)-induced POF model.<h4>Methods</h4>HuMSCs-Exos were characterized using transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and western blot for exosomal markers. A CTX-induced POF mouse model was treated with HuMSCs-Exos to assess their impact on ovarian morphology, function, and fertility. A"],"journal":["Journal of ovarian research"],"pubmed_title":["Exosomes derived from mesenchymal stem cells repair ovarian function by suppressing NLRP3-mediated pyroptosis in cyclophosphamide-induced premature ovarian failure."],"pmcid":["PMC12487243"],"funding_grant_id":["201901D211519"],"pubmed_authors":["Li H","Jing X","Xue T","Wang S","Huang X","Cui X","Zhu X"],"additional_accession":[]},"is_claimable":false,"name":"Exosomes derived from mesenchymal stem cells repair ovarian function by suppressing NLRP3-mediated pyroptosis in cyclophosphamide-induced premature ovarian failure.","description":"<h4>Background</h4>Premature ovarian failure (POF) is a debilitating condition impairing fertility and health in women. Mesenchymal stem cell-derived exosomes (MSC-EVs) have emerged as a promising therapeutic option for POF due to their regenerative capabilities. This study explores the effectiveness of human umbilical cord mesenchymal stem cell-derived exosomes (HuMSCs-Exos) in counteracting NLRP3-mediated pyroptosis and restoring ovarian function in a cyclophosphamide (CTX)-induced POF model.<h4>Methods</h4>HuMSCs-Exos were characterized using transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and western blot for exosomal markers. A CTX-induced POF mouse model was treated with HuMSCs-Exos to assess their impact on ovarian morphology, function, and fertility. A","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-04T03:14:13.121Z","creation":"2026-05-04T03:13:03.088Z"},"accession":"S-EPMC12487243","cross_references":{"pubmed":["41034911"],"doi":["10.1186/s13048-025-01785-1"]}}