biostudies-literatureUnknown25(1)Abu Hamdeh N<h4>Background</h4>Multiple myeloma (MM) substantially impairs health-related quality of life (QoL). Evidence from low- and middle-income countries is limited, and identifying reliable predictors of QoL is essential to guide supportive care strategies.<h4>Methods</h4>We conducted a multicenter cross-sectional study of 202 MM patients from six hospitals in the West Bank, Palestine (2018-2025). Patients completed the validated Arabic EORTC QLQ-MY20 questionnaire. Clinical, demographic, and therapeutic variables were collected, and predictors of QoL subscales were analyzed using non-parametric tests and multivariable linear regression with LASSO variable selection.<h4>Results</h4>In the Side Effects of Treatment subscale, abdominal pain (β = 6.75; 95% CI: 1.92-11.59; p = 0.006), chest pain (βBMC cancer1472https://www.ebi.ac.uk/biostudies/studies/S-EPMC12487296biostudies-literaturePredictors of quality of life in multiple myeloma patients: a multi-centered cross-sectional study.PMC12487296Shaheen LIhmoud FAlawna AAbdul-Hafez HAAbu Khadija HAtallah SDweikat OAAKhaleel ASalloum OAbu Hamdeh NZahran AAhmad MMYaghmour RRiyad NBarq AAbuAlrub IBali BMasu'd MHadya FAlnees MSalah QEwidat OZayed AIsmail SAbuAlsuod ENajajra DZraiq SDarwish AAllaham SMarrawani MAlzirei KfalsePredictors of quality of life in multiple myeloma patients: a multi-centered cross-sectional study.<h4>Background</h4>Multiple myeloma (MM) substantially impairs health-related quality of life (QoL). Evidence from low- and middle-income countries is limited, and identifying reliable predictors of QoL is essential to guide supportive care strategies.<h4>Methods</h4>We conducted a multicenter cross-sectional study of 202 MM patients from six hospitals in the West Bank, Palestine (2018-2025). Patients completed the validated Arabic EORTC QLQ-MY20 questionnaire. Clinical, demographic, and therapeutic variables were collected, and predictors of QoL subscales were analyzed using non-parametric tests and multivariable linear regression with LASSO variable selection.<h4>Results</h4>In the Side Effects of Treatment subscale, abdominal pain (β = 6.75; 95% CI: 1.92-11.59; p = 0.006), chest pain (β2025-01-01T00:00:00Z2025 Sep2026-06-04T01:23:06.088Z2026-05-03T03:14:03.372ZS-EPMC124872964102925810.1186/s12885-025-14960-w