biostudies-literatureShimogama TJapan Society for the Promotion of Science1039https://www.ebi.ac.uk/biostudies/studies/S-EPMC12487302biostudies-literatureUnknown23(1)<h4>Objective</h4>Increasing evidence indicated substantial involvement of non-Helicobacter pylori microbiota in gastric tumorigenesis. We aimed to elucidate detailed relationship of microbiome dynamics between two different steps in gastric cancer (GC) such as cancer initiation and progression, and assessed their associations with clinicopathological and molecular changes.<h4>Methods</h4>We systemically characterized gastric microbiome during GC initiation and progression using 944 biopsies from primary GC, non-cancerous gastric mucosa from both GC and non-cancer subjects. The association between specific microbial characteristics and GC risk, prognosis and molecular changes such as TP53 mutation, DNA methylation and telomere shortening were also evaluated.<h4>Results</h4>Microbial α-diveJournal of translational medicineGastric microbiome in gastric cancer sequence depicts diverse microbial structures associated with cancer risk and prognosis.PMC1248730222K08089Yamazaki JNakamura NTomiyama TFukui TShijimaya TShimogama TKobayashi SNaganuma MTahara THonzawa YTakahashi YfalseGastric microbiome in gastric cancer sequence depicts diverse microbial structures associated with cancer risk and prognosis.<h4>Objective</h4>Increasing evidence indicated substantial involvement of non-Helicobacter pylori microbiota in gastric tumorigenesis. We aimed to elucidate detailed relationship of microbiome dynamics between two different steps in gastric cancer (GC) such as cancer initiation and progression, and assessed their associations with clinicopathological and molecular changes.<h4>Methods</h4>We systemically characterized gastric microbiome during GC initiation and progression using 944 biopsies from primary GC, non-cancerous gastric mucosa from both GC and non-cancer subjects. The association between specific microbial characteristics and GC risk, prognosis and molecular changes such as TP53 mutation, DNA methylation and telomere shortening were also evaluated.<h4>Results</h4>Microbial α-dive2025-01-01T00:00:00Z2025 Oct2026-06-04T02:29:55.751Z2026-05-04T03:13:42.104ZS-EPMC124873024103503410.1186/s12967-025-07046-5