biostudies-literatureWang MSun Yat-sen Pilot Scientific Research Fund3164https://www.ebi.ac.uk/biostudies/studies/S-EPMC12487353biostudies-literatureUnknown25(1)<h4>Background</h4>Studies from several countries have reported an increasing trend in heart failure (HF) among young adults, but comprehensive data on HF burden among young Chinese adults are lacking.<h4>Methods</h4>Using data from the Global Burden of Disease Study 2021, we analyzed trends in prevalence and years lived with disability (YLDs) of HF among Chinese adults aged 20-49 years from 1990 to 2021. We examined age-standardized rates per 100,000 population, stratified by age groups, sex, severity levels, and underlying causes. Joinpoint regression, age-period-cohort analysis, decomposition analysis, frontier analysis and projection models were applied.<h4>Results</h4>From 1990 to 2021, HF prevalence cases increased from 448,261.89 to 897,595.61, while YLDs rose from 44,025.76 to 88,4BMC public healthTemporal trends in heart failure burden among young adults in China: a systematic analysis from 1990 to 2021.PMC12487353YXQH202206Wang MLiao ZHuang SCao MHuang HHuang XFu GfalseTemporal trends in heart failure burden among young adults in China: a systematic analysis from 1990 to 2021.<h4>Background</h4>Studies from several countries have reported an increasing trend in heart failure (HF) among young adults, but comprehensive data on HF burden among young Chinese adults are lacking.<h4>Methods</h4>Using data from the Global Burden of Disease Study 2021, we analyzed trends in prevalence and years lived with disability (YLDs) of HF among Chinese adults aged 20-49 years from 1990 to 2021. We examined age-standardized rates per 100,000 population, stratified by age groups, sex, severity levels, and underlying causes. Joinpoint regression, age-period-cohort analysis, decomposition analysis, frontier analysis and projection models were applied.<h4>Results</h4>From 1990 to 2021, HF prevalence cases increased from 448,261.89 to 897,595.61, while YLDs rose from 44,025.76 to 88,42025-01-01T00:00:00Z2025 Sep2026-06-04T01:28:27.877Z2026-05-03T03:14:16.831ZS-EPMC124873534102957510.1186/s12889-025-23623-1