biostudies-literatureHuang MBasic Scientific Research Funds of Department of Education of Zhejiang ProvinceZhejiang Medical and Health Science and Technology Plan Projectthe administration of traditional Chinese Medicine of Zhejiang provincethe Natural Science Foundation of Zhejiang Provincethe National Natural Science Foundation of China152https://www.ebi.ac.uk/biostudies/studies/S-EPMC12487359biostudies-literatureUnknown20(1)<h4>Background</h4>Ulcerative colitis (UC), a chronic inflammatory bowel disease, remains an unmet medical need. Lindera aggregata, a traditional Chinese medicine used in treating gastrointestinal disorders, has demonstrated anti-UC efficacy, though its bioactive components are poorly characterized. Isolinderalactone (ILDL), a characteristic sesquiterpene lactone isolated from Lindera aggregata, has been demonstrated anti-cancer properties. However, its therapeutic potential in UC remains unexplored.<h4>Methods</h4>Lipopolysaccharide (LPS)-induced RAW264.7 inflammatory cell model was used to screen the anti-inflammatory properties of Lindera aggregata's characteristic compounds in vitro. DSS induced UC mouse model was used to study the anti-UC efficacy of ILDL in vivo. Transcriptomic was uChinese medicineIsolinderalactone regulates macrophage polarization and efferocytosis by activating the LXRα pathway against ulcerative colitis.PMC124873592024KY917GZY-KJS-ZJ-2025-080, 2024ZF056KYYB2023002, KYYB2023017LMS25H280001, LMS25H030001, Q24H28006482300589, 82360805Zeng LLi FHuang MZhao YShi YLiu XDou XLi YLin CLiang GLan MXu XSun JfalseIsolinderalactone regulates macrophage polarization and efferocytosis by activating the LXRα pathway against ulcerative colitis.<h4>Background</h4>Ulcerative colitis (UC), a chronic inflammatory bowel disease, remains an unmet medical need. Lindera aggregata, a traditional Chinese medicine used in treating gastrointestinal disorders, has demonstrated anti-UC efficacy, though its bioactive components are poorly characterized. Isolinderalactone (ILDL), a characteristic sesquiterpene lactone isolated from Lindera aggregata, has been demonstrated anti-cancer properties. However, its therapeutic potential in UC remains unexplored.<h4>Methods</h4>Lipopolysaccharide (LPS)-induced RAW264.7 inflammatory cell model was used to screen the anti-inflammatory properties of Lindera aggregata's characteristic compounds in vitro. DSS induced UC mouse model was used to study the anti-UC efficacy of ILDL in vivo. Transcriptomic was u2025-01-01T00:00:00Z2025 Oct2026-06-04T01:51:47.559Z2026-05-04T03:14:13.741ZS-EPMC124873594102987010.1186/s13020-025-01216-9