{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gupta A"],"funding":["Ministry of Education - Singapore"],"pagination":["404"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12487525"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>Advancements in chemotherapy have improved outcomes for rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children. However, relapse-free survival rates remain below 20% in metastatic alveolar rhabdomyosarcoma (ARMS). Tumor-initiating cells (TICs) drive recurrence. Targeting this pool of cells has been shown to reduce relapse rates and metastasis in various cancers. Emerging evidence implicates lipid metabolism in supporting stem-like properties in cancer. However, TICs remain poorly characterized in ARMS. This study investigates the transcriptomic and metabolic profile of TICs in ARMS.<h4>Methods</h4>Transcriptomic and lipidomic profiling were performed on tumorsphere-derived and adherent cells from ARMS cells. Differential expression of metabolic genes and"],"journal":["Cell communication and signaling : CCS"],"pubmed_title":["PLA2 driven lipid signaling drives ARMS tumorigenic cell properties."],"pmcid":["PMC12487525"],"funding_grant_id":["MOE-T2EP30222-0014"],"pubmed_authors":["Ramanathan B","Gupta A","Loh AHP","Das D","Taneja R","Vadivellu A"],"additional_accession":[]},"is_claimable":false,"name":"PLA2 driven lipid signaling drives ARMS tumorigenic cell properties.","description":"<h4>Background</h4>Advancements in chemotherapy have improved outcomes for rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children. However, relapse-free survival rates remain below 20% in metastatic alveolar rhabdomyosarcoma (ARMS). Tumor-initiating cells (TICs) drive recurrence. Targeting this pool of cells has been shown to reduce relapse rates and metastasis in various cancers. Emerging evidence implicates lipid metabolism in supporting stem-like properties in cancer. However, TICs remain poorly characterized in ARMS. This study investigates the transcriptomic and metabolic profile of TICs in ARMS.<h4>Methods</h4>Transcriptomic and lipidomic profiling were performed on tumorsphere-derived and adherent cells from ARMS cells. Differential expression of metabolic genes and","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T04:21:09.783Z","creation":"2026-05-04T03:14:17.725Z"},"accession":"S-EPMC12487525","cross_references":{"pubmed":["41034946"],"doi":["10.1186/s12964-025-02409-3"]}}