biostudies-literatureUnknownSmith DMNIAID NIH HHS<h4>Background</h4>Tobacco-cannabis co-use is more common than exclusive cannabis use, and is linked to more severe tobacco and cannabis health consequences. We assessed trends and predictors of tobacco-cannabis co-use and their link to future substance use problems and severity among Black and Hispanic adolescent and young adult (AYA) females living in New York City.<h4>Methods</h4>Secondary data were analyzed from a seven year (2013-2020) prospective open cohort study conducted at Mount Sinai Adolescent Health Center in New York City (n=1,281). Participants completed questionnaires every six months, and self-reported information on use of smoked tobacco, cannabis, and blunts/spliffs; sexual risk behaviors, depressive symptoms, and other substance use. Regression analyses examined initiatInternational journal of mental health and addictionhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC12487647biostudies-literatureTobacco-cannabis co-use and risk of substance use problems among Black and Hispanic adolescent and young adult females in New York City.PMC12487647R01 AI072204Diaz AShyhalla KSchlecht NFViswanathan SNucci-Sack ASmith DMBurk RDfalseTobacco-cannabis co-use and risk of substance use problems among Black and Hispanic adolescent and young adult females in New York City.<h4>Background</h4>Tobacco-cannabis co-use is more common than exclusive cannabis use, and is linked to more severe tobacco and cannabis health consequences. We assessed trends and predictors of tobacco-cannabis co-use and their link to future substance use problems and severity among Black and Hispanic adolescent and young adult (AYA) females living in New York City.<h4>Methods</h4>Secondary data were analyzed from a seven year (2013-2020) prospective open cohort study conducted at Mount Sinai Adolescent Health Center in New York City (n=1,281). Participants completed questionnaires every six months, and self-reported information on use of smoked tobacco, cannabis, and blunts/spliffs; sexual risk behaviors, depressive symptoms, and other substance use. Regression analyses examined initiat2024-01-01T00:00:00Z2024 Jul2026-06-04T02:22:15.778Z2026-05-04T03:13:41.93ZS-EPMC124876474104081610.1007/s11469-024-01355-4