{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["646(8083)"],"submitter":["Sheng M"],"pubmed_abstract":["Motor skill learning induces long-lasting synaptic plasticity at dendritic spines<sup>1-4</sup> and at the outputs of motor cortical neurons to the striatum<sup>5,6</sup>. However, little is known about corticostriatal axon activity and structural plasticity during learning in the adult brain. Here, using longitudinal in vivo two-photon imaging, we tracked thousands of corticostriatal axonal boutons in the dorsolateral striatum of awake mice. We found that learning a new motor skill dynamically regulated these boutons. The activities of motor corticostriatal axonal boutons exhibited selectivity for rewarded movements (RM) and unrewarded movements (UM). Notably, boutons on the same axonal branches showed diverse responses during behaviour. Motor learning significantly increased the proporti"],"journal":["Nature"],"pagination":["143-151"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12488484"],"repository":["biostudies-literature"],"pubmed_title":["Remodelling of corticostriatal axonal boutons during motor learning."],"pmcid":["PMC12488484"],"pubmed_authors":["Hwang FJ","Sheng K","Sheng M","Ding JB","Lu D","Roth RH"],"additional_accession":[]},"is_claimable":false,"name":"Remodelling of corticostriatal axonal boutons during motor learning.","description":"Motor skill learning induces long-lasting synaptic plasticity at dendritic spines<sup>1-4</sup> and at the outputs of motor cortical neurons to the striatum<sup>5,6</sup>. However, little is known about corticostriatal axon activity and structural plasticity during learning in the adult brain. Here, using longitudinal in vivo two-photon imaging, we tracked thousands of corticostriatal axonal boutons in the dorsolateral striatum of awake mice. We found that learning a new motor skill dynamically regulated these boutons. The activities of motor corticostriatal axonal boutons exhibited selectivity for rewarded movements (RM) and unrewarded movements (UM). Notably, boutons on the same axonal branches showed diverse responses during behaviour. Motor learning significantly increased the proporti","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T01:27:11.769Z","creation":"2026-05-03T03:14:13.321Z"},"accession":"S-EPMC12488484","cross_references":{"pubmed":["40739352"],"doi":["10.1038/s41586-025-09336-w"]}}