{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen M"],"funding":["Ministerio de Ciencia, Tecnología e Innovación","Swiss National Science Foundation","Gobierno de Aragón"],"pagination":["1458-1474"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12489286"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["248(3)"],"pubmed_abstract":["In symbiotic plant-microbe interactions, the host invests considerable amounts of resources in the microbial partner. If the microbe does not reciprocate with a comparable symbiotic benefit, it is regarded as a cheater. The host responds to cheaters with negative feedback mechanisms (sanctions) to prevent fitness deficits resulting from being exploited. We study sanctioning in the symbiosis between Medicago truncatula and the nitrogen-fixing rhizobium Sinorhizobium meliloti. We manipulated the exchange of resources between the partners in three ways: by using mutant rhizobia defective in nitrogenase; replacing nitrogen in the atmosphere with argon gas; and supplying rich nitrogen fertilizer to the host. We follow the consequences of simulated cheating by examining the metabolome and proteo"],"journal":["The New phytologist"],"pubmed_title":["Inhibition of rhizobial cheaters by the host Medicago truncatula involves repression of symbiotic functions and induction of defense."],"pmcid":["PMC12489286"],"funding_grant_id":["E35_23R","MCIN/AEI/10.13039/501100011033","310030","200367","310030_200367"],"pubmed_authors":["Raisin A","Yruela I","Allard PM","Stumpe M","Reinhardt D","Chen M","Judkins N","Defossez E","Becana M"],"additional_accession":[]},"is_claimable":false,"name":"Inhibition of rhizobial cheaters by the host Medicago truncatula involves repression of symbiotic functions and induction of defense.","description":"In symbiotic plant-microbe interactions, the host invests considerable amounts of resources in the microbial partner. If the microbe does not reciprocate with a comparable symbiotic benefit, it is regarded as a cheater. The host responds to cheaters with negative feedback mechanisms (sanctions) to prevent fitness deficits resulting from being exploited. We study sanctioning in the symbiosis between Medicago truncatula and the nitrogen-fixing rhizobium Sinorhizobium meliloti. We manipulated the exchange of resources between the partners in three ways: by using mutant rhizobia defective in nitrogenase; replacing nitrogen in the atmosphere with argon gas; and supplying rich nitrogen fertilizer to the host. We follow the consequences of simulated cheating by examining the metabolome and proteo","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-04T01:54:05.717Z","creation":"2026-05-04T03:14:08.254Z"},"accession":"S-EPMC12489286","cross_references":{"pubmed":["40910153"],"doi":["10.1111/nph.70494"]}}