biostudies-literatureBerrio-Valencia MICanadian Institutes of Health Research582-593https://www.ebi.ac.uk/biostudies/studies/S-EPMC12489362biostudies-literatureUnknown135(3)<h4>Background</h4>Prehabilitation is hypothesised to play an important role in optimising postoperative outcomes. However, achieving high adherence can be challenging. Our objectives were to synthesise current approaches to adherence measurement and reporting, estimate prehabilitation adherence across trials, identify procedural-, programme-, or patient-level factors associated with adherence, and report barriers and facilitators to adherence.<h4>Methods</h4>Ovid MEDLINE, Embase, the CINAHL, PsycINFO, Web of Science, and the Cochrane CENTRAL Register of Controlled Trials were searched from inception until April 10, 2024. We included randomised trials of adults undergoing major elective surgery allocated to a prehabilitation programme, with at least one binary or continuous measure of adheBritish journal of anaesthesiaAdherence to prehabilitation in adult surgical patients: a systematic review, meta-analysis, meta-regression, and qualitative synthesis.PMC12489362202109PJKHladkowicz EBoet SWolfe DMAl-Bayati MCanadian Prehabilitation Knowledge NetworkLalu MKidd GHutton BMcIsaac DIBranje KChitiva-Martinez IBerrio-Valencia MIBaxi AGillis CfalseAdherence to prehabilitation in adult surgical patients: a systematic review, meta-analysis, meta-regression, and qualitative synthesis.<h4>Background</h4>Prehabilitation is hypothesised to play an important role in optimising postoperative outcomes. However, achieving high adherence can be challenging. Our objectives were to synthesise current approaches to adherence measurement and reporting, estimate prehabilitation adherence across trials, identify procedural-, programme-, or patient-level factors associated with adherence, and report barriers and facilitators to adherence.<h4>Methods</h4>Ovid MEDLINE, Embase, the CINAHL, PsycINFO, Web of Science, and the Cochrane CENTRAL Register of Controlled Trials were searched from inception until April 10, 2024. We included randomised trials of adults undergoing major elective surgery allocated to a prehabilitation programme, with at least one binary or continuous measure of adhe2025-01-01T00:00:00Z2025 Sep2026-06-04T01:28:25.673Z2026-05-03T03:14:16.64ZS-EPMC124893624061532810.1016/j.bja.2025.06.003