{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang L"],"funding":["T. T. and W. F. Chao Foundation","Cure Alzheimer's Fund","NIA NIH HHS","Houston Methodist Cornerstone Award","John S. Dunn Research Foundation","NIH HHS","Paul Richard Jeanneret Research Fund"],"pagination":["e70603"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12489747"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(10)"],"pubmed_abstract":["<h4>Introduction</h4>Obesity is a major modifiable risk factor for Alzheimer's disease (AD), but the mechanistic link between peripheral metabolic dysfunction and AD progression remains unclear. Adipose-derived extracellular vesicles (EVs) may penetrate the brain and alter lipid homeostasis, contributing to neurodegeneration.<h4>Methods</h4>We isolated exosome-enriched EVs from subcutaneous and visceral fat of lean and obese individuals, followed by lipidomic profiling. An in vitro amyloid-β (Aβ) aggregation assay using purified Aβ40 and Aβ42 peptides was performed under lipid environments mimicking physiological and pathological states.<h4>Results</h4>Obese-derived EVs exhibited distinct lipid profiles, particularly in lysophosphatidylcholine (LPC) and sphingomyelin (SM) species. Function"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Decoding adipose-brain crosstalk: Distinct lipid cargo in human adipose-derived extracellular vesicles modulates amyloid aggregation in Alzheimer's disease."],"pmcid":["PMC12489747"],"funding_grant_id":["U01CA253553","P30 AG013319","R01CA238727","R01AG057635","P30 AG044271"],"pubmed_authors":["Sheng J","Yang L","Chan M","Reategui E","Han X","Wong STC","Hsueh WA","Shantaram D","Qi S","Rima XY","Chan B"],"additional_accession":[]},"is_claimable":false,"name":"Decoding adipose-brain crosstalk: Distinct lipid cargo in human adipose-derived extracellular vesicles modulates amyloid aggregation in Alzheimer's disease.","description":"<h4>Introduction</h4>Obesity is a major modifiable risk factor for Alzheimer's disease (AD), but the mechanistic link between peripheral metabolic dysfunction and AD progression remains unclear. Adipose-derived extracellular vesicles (EVs) may penetrate the brain and alter lipid homeostasis, contributing to neurodegeneration.<h4>Methods</h4>We isolated exosome-enriched EVs from subcutaneous and visceral fat of lean and obese individuals, followed by lipidomic profiling. An in vitro amyloid-β (Aβ) aggregation assay using purified Aβ40 and Aβ42 peptides was performed under lipid environments mimicking physiological and pathological states.<h4>Results</h4>Obese-derived EVs exhibited distinct lipid profiles, particularly in lysophosphatidylcholine (LPC) and sphingomyelin (SM) species. Function","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T02:29:24.948Z","creation":"2026-05-04T03:13:36.126Z"},"accession":"S-EPMC12489747","cross_references":{"pubmed":["41036709"],"doi":["10.1002/alz.70603"]}}