{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["44"],"submitter":["Fathima I"],"pubmed_abstract":["<h4>Background</h4>MAST2 (Microtubule-Associated Serine/Threonine Kinase 2) is an enigmatic serine/threonine kinase that is considered to bridge microtubule-associated cytoskeletal architecture through its phospho-regulatory networks. Yet, MAST2 remains a dark horse in the human kinome, as the molecular details on its structure, upstream regulators, and downstream phosphorylation targets remain unknown.<h4>Methods and results</h4>To interpret MAST2-linked phospho-signaling dynamics, PubMed-indexed articles were curated based on predefined MeSH terms to obtain global cellular phosphoproteomics datasets. Among 105 class I phosphosites in MAST2 identified across cellular phosphoproteomics datasets, 2 phosphosites, S74 and S148, were represented more abundantly compared to other phosphosites, "],"journal":["Biochemistry and biophysics reports"],"pagination":["102277"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12489769"],"repository":["biostudies-literature"],"pubmed_title":["Cellular phospho-signaling map of the enigmatic serine/threonine kinase MAST2."],"pmcid":["PMC12489769"],"pubmed_authors":["Nishana A","Priyanka P","Naurah Vattoth N","Perunelly Gopalakrishnan A","Fathima I","Mahin A","Raju R","Soman S"],"additional_accession":[]},"is_claimable":false,"name":"Cellular phospho-signaling map of the enigmatic serine/threonine kinase MAST2.","description":"<h4>Background</h4>MAST2 (Microtubule-Associated Serine/Threonine Kinase 2) is an enigmatic serine/threonine kinase that is considered to bridge microtubule-associated cytoskeletal architecture through its phospho-regulatory networks. Yet, MAST2 remains a dark horse in the human kinome, as the molecular details on its structure, upstream regulators, and downstream phosphorylation targets remain unknown.<h4>Methods and results</h4>To interpret MAST2-linked phospho-signaling dynamics, PubMed-indexed articles were curated based on predefined MeSH terms to obtain global cellular phosphoproteomics datasets. Among 105 class I phosphosites in MAST2 identified across cellular phosphoproteomics datasets, 2 phosphosites, S74 and S148, were represented more abundantly compared to other phosphosites, ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-01T03:15:42.096Z","creation":"2026-06-01T03:06:26.836Z"},"accession":"S-EPMC12489769","cross_references":{"pubmed":["41049126"],"doi":["10.1016/j.bbrep.2025.102277"]}}