{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Agredo P"],"funding":["University of Rochester","Innovation and Technology Ecosystems","U.S. Army Medical Research Acquisition Activity"],"pagination":["25962-25969"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12490004"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(38)"],"pubmed_abstract":["Fluorenylmethoxycarbonyl-phenylalanine (Fmoc-Phe) derivatives are a privileged molecular class that readily undergoes supramolecular self-assembly into hydrogel networks. Herein, we characterize the self-assembly properties of xylene-derived constitutional isomers of Fmoc-Phe, demonstrating the impact of molecular configuration on the emergent structure and properties of supramolecular assemblies of these derivatives. The self-assembly properties of Fmoc-Phe and a cationic derivative of Fmoc-Phe that has been modified at the C terminus with diaminopropane (DAP), Fmoc-Phe-DAP, were compared to those of several corresponding xylene derivatives in which Fmoc-functionalized amine and carboxylic acid or DAP-functionalized carboxylic acid are organized around a central benzene ring, with the app"],"journal":["Langmuir : the ACS journal of surfaces and colloids"],"pubmed_title":["Self-Assembly Properties of Xylene-Derived Constitutional Isomers of Fmoc-Phenylalanine."],"pmcid":["PMC12490004"],"funding_grant_id":["ITE-2344389","W81XWH-20-1-0112"],"pubmed_authors":["Agredo P","Carter ST","Nilsson BL","Mohan R"],"additional_accession":[]},"is_claimable":false,"name":"Self-Assembly Properties of Xylene-Derived Constitutional Isomers of Fmoc-Phenylalanine.","description":"Fluorenylmethoxycarbonyl-phenylalanine (Fmoc-Phe) derivatives are a privileged molecular class that readily undergoes supramolecular self-assembly into hydrogel networks. Herein, we characterize the self-assembly properties of xylene-derived constitutional isomers of Fmoc-Phe, demonstrating the impact of molecular configuration on the emergent structure and properties of supramolecular assemblies of these derivatives. The self-assembly properties of Fmoc-Phe and a cationic derivative of Fmoc-Phe that has been modified at the C terminus with diaminopropane (DAP), Fmoc-Phe-DAP, were compared to those of several corresponding xylene derivatives in which Fmoc-functionalized amine and carboxylic acid or DAP-functionalized carboxylic acid are organized around a central benzene ring, with the app","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-04T01:30:37.289Z","creation":"2026-05-03T03:13:58.447Z"},"accession":"S-EPMC12490004","cross_references":{"pubmed":["40963276"],"doi":["10.1021/acs.langmuir.5c02581"]}}