{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(9)"],"submitter":["Wang W"],"pubmed_abstract":["Oxidative damage and neuroinflammation are the key features of central nervous system (CNS) injury. Inspired by the neuroprotective properties of neural stem cell-derived exosomes (NExo) and the reactive oxygen species (ROS) scavenging ability of selenium, we develop an advanced NExo bearing ultrasmall nano-selenium (∼3.5 nm) via lipid-mediated nucleation (SeNExo). In addition to maintaining the biological components of NExo, the resulting SeNExo exhibits a Se-O bond that dramatically enhances its ROS-scavenging performance. SeNExo penetrates the blood-brain barrier (BBB) via the apolipoprotein E and prolow-density lipoprotein receptor-related protein 1 (APOE_LRP-1) interaction. Through proteomics, microRNA (miRNA) omics, and single-nucleus RNA sequencing, we find that SeNExo can alleviate"],"journal":["Cell reports. Medicine"],"pagination":["102319"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12490213"],"repository":["biostudies-literature"],"pubmed_title":["Selenized neural stem cell-derived exosomes: A neotype therapeutic agent for traumatic injuries of the central nervous system."],"pmcid":["PMC12490213"],"pubmed_authors":["Tan H","Qin M","Zhang H","Wang D","Li F","Wei W","Lyu C","Guo P","Li W","Lu G","Li S","Wang W","Wang Y","Zhao J","Zheng D","Ma G"],"additional_accession":[]},"is_claimable":false,"name":"Selenized neural stem cell-derived exosomes: A neotype therapeutic agent for traumatic injuries of the central nervous system.","description":"Oxidative damage and neuroinflammation are the key features of central nervous system (CNS) injury. Inspired by the neuroprotective properties of neural stem cell-derived exosomes (NExo) and the reactive oxygen species (ROS) scavenging ability of selenium, we develop an advanced NExo bearing ultrasmall nano-selenium (∼3.5 nm) via lipid-mediated nucleation (SeNExo). In addition to maintaining the biological components of NExo, the resulting SeNExo exhibits a Se-O bond that dramatically enhances its ROS-scavenging performance. SeNExo penetrates the blood-brain barrier (BBB) via the apolipoprotein E and prolow-density lipoprotein receptor-related protein 1 (APOE_LRP-1) interaction. Through proteomics, microRNA (miRNA) omics, and single-nucleus RNA sequencing, we find that SeNExo can alleviate","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-04T01:51:13.592Z","creation":"2026-05-04T03:14:09.966Z"},"accession":"S-EPMC12490213","cross_references":{"pubmed":["40882623"],"doi":["10.1016/j.xcrm.2025.102319"]}}