{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wan H"],"funding":["Vetenskapsrådet","O. E. och Edla Johanssons Vetenskapliga Stiftelse","Knut and Alice Wallenberg Foundation","Karolinska Institutet","Swedish Cancer Society","Cancer Research Foundations of Radiumhemmet"],"pagination":["102318"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12490240"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(9)"],"pubmed_abstract":["Mantle cell lymphoma (MCL) is a rare but often aggressive type of B cell lymphoma with a high risk of relapse. To explore intratumoral clonal diversity and tumor evolution related to disease relapse, we integrate single-cell RNA and B cell receptor sequencing with whole-genome sequencing in 20 diagnosed/untreated and/or relapsed samples from 11 MCL patients. Our results reveal significant intratumor heterogeneity in MCL already at diagnosis. We further show that the evolutionary paths during disease progression for each patient are unique, where minor clones present at diagnosis may acquire different mutations and copy-number variations and/or migrate to various microenvironments. Despite significant interpatient heterogeneity, recurrent genetic and transcriptomic changes in tumor cells af"],"journal":["Cell reports. Medicine"],"pubmed_title":["Tumor evolution and immune microenvironment dynamics in primary and relapsed mantle cell lymphoma."],"pmcid":["PMC12490240"],"funding_grant_id":["2022-06725","naiss2024-22-1443"],"pubmed_authors":["Wu K","Ren W","Berglund M","Yang M","de Campos-Mata L","Nie M","Bai Z","Yang C","Ye X","Fan R","van der Burg M","Ansell SM","Sander B","Li X","Yang ZZ","Sun R","Wasik AM","Wan H","Wang Y","Liu D","Pan-Hammarstrom Q","Du L","Amini RM","Enninful A"],"additional_accession":[]},"is_claimable":false,"name":"Tumor evolution and immune microenvironment dynamics in primary and relapsed mantle cell lymphoma.","description":"Mantle cell lymphoma (MCL) is a rare but often aggressive type of B cell lymphoma with a high risk of relapse. To explore intratumoral clonal diversity and tumor evolution related to disease relapse, we integrate single-cell RNA and B cell receptor sequencing with whole-genome sequencing in 20 diagnosed/untreated and/or relapsed samples from 11 MCL patients. Our results reveal significant intratumor heterogeneity in MCL already at diagnosis. We further show that the evolutionary paths during disease progression for each patient are unique, where minor clones present at diagnosis may acquire different mutations and copy-number variations and/or migrate to various microenvironments. Despite significant interpatient heterogeneity, recurrent genetic and transcriptomic changes in tumor cells af","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-04T00:21:33.87Z","creation":"2026-05-03T03:12:08.451Z"},"accession":"S-EPMC12490240","cross_references":{"pubmed":["40876452"],"doi":["10.1016/j.xcrm.2025.102318"]}}