{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Hoheisel F"],"pubmed_abstract":["<h4>Introduction</h4>Epstein-Barr virus (EBV) infection is a well-established trigger and risk factor for both myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-COVID syndrome (PCS). In previous studies, we identified elevated IgG responses to arginine-rich (poly-R) sequences within the EBV nuclear antigens EBNA4 and EBNA6 in post-infectious ME/CFS (piME/CFS). Building on these findings, this exploratory study examines IgG reactivity to poly-R-containing EBV-derived peptides and homologous human peptides in women with PCS and ME/CFS.<h4>Methods</h4>IgG reactivity to poly-R containing peptides derived from EBNA4 and EBNA6, and homologous human 15-mer peptides and the corresponding full-length proteins, was assessed using a cytometric bead array (CBA) and a multiplex dot-b"],"journal":["Frontiers in immunology"],"pagination":["1650948"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12491002"],"repository":["biostudies-literature"],"pubmed_title":["Exploratory study on autoantibodies to arginine-rich human peptides mimicking Epstein-Barr virus in women with post-COVID and myalgic encephalomyelitis/chronic fatigue syndrome."],"pmcid":["PMC12491002"],"pubmed_authors":["Sotzny F","Fleischer KM","Mautner J","Wittke K","Seifert M","Hoheisel F","Stein AE","Konietschke F","Rubarth K","Bauer S","Sepulveda N","Kedor Peters C","Scheibenbogen C","Behrends U","Bellmann-Strobl J"],"additional_accession":[]},"is_claimable":false,"name":"Exploratory study on autoantibodies to arginine-rich human peptides mimicking Epstein-Barr virus in women with post-COVID and myalgic encephalomyelitis/chronic fatigue syndrome.","description":"<h4>Introduction</h4>Epstein-Barr virus (EBV) infection is a well-established trigger and risk factor for both myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-COVID syndrome (PCS). In previous studies, we identified elevated IgG responses to arginine-rich (poly-R) sequences within the EBV nuclear antigens EBNA4 and EBNA6 in post-infectious ME/CFS (piME/CFS). Building on these findings, this exploratory study examines IgG reactivity to poly-R-containing EBV-derived peptides and homologous human peptides in women with PCS and ME/CFS.<h4>Methods</h4>IgG reactivity to poly-R containing peptides derived from EBNA4 and EBNA6, and homologous human 15-mer peptides and the corresponding full-length proteins, was assessed using a cytometric bead array (CBA) and a multiplex dot-b","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-04T05:18:09.603Z","creation":"2026-05-31T03:07:14.855Z"},"accession":"S-EPMC12491002","cross_references":{"pubmed":["41050647"],"doi":["10.3389/fimmu.2025.1650948"]}}