{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(10)"],"submitter":["Mordier J"],"funding":["Agence Nationale de la Recherche","Institute of Genetics","Fondation pour la Recherche Médicale"],"pubmed_abstract":["SCHLAFEN proteins are a large family of RNase-related enzymes carrying essential immune and developmental functions. Despite these important roles, Schlafen genes display varying degrees of evolutionary conservation in mammals. While this appears to influence their molecular activities, a detailed understanding of these evolutionary innovations is still lacking. Here, we used in-depth phylogenomic approaches to characterize the evolutionary trajectories and selective forces shaping mammalian Schlafen genes. We traced lineage-specific Schlafen amplifications and found that recent duplicates evolved under distinct selective forces, supporting repeated subfunctionalization cycles. Codon-level natural selection analyses in primates and rodents identified recurrent positive selection over Schla"],"journal":["Genome biology and evolution"],"pagination":["evaf172"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12492265"],"repository":["biostudies-literature"],"pubmed_title":["Recurrent Evolutionary Innovations in Rodent and Primate Schlafen Genes."],"pmcid":["PMC12492265"],"pubmed_authors":["Molaro A","Fraisse M","Mordier J","Cohen-Tannoudji M"],"additional_accession":[]},"is_claimable":false,"name":"Recurrent Evolutionary Innovations in Rodent and Primate Schlafen Genes.","description":"SCHLAFEN proteins are a large family of RNase-related enzymes carrying essential immune and developmental functions. Despite these important roles, Schlafen genes display varying degrees of evolutionary conservation in mammals. While this appears to influence their molecular activities, a detailed understanding of these evolutionary innovations is still lacking. Here, we used in-depth phylogenomic approaches to characterize the evolutionary trajectories and selective forces shaping mammalian Schlafen genes. We traced lineage-specific Schlafen amplifications and found that recent duplicates evolved under distinct selective forces, supporting repeated subfunctionalization cycles. Codon-level natural selection analyses in primates and rodents identified recurrent positive selection over Schla","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-09T03:10:53.864Z","creation":"2026-05-09T03:08:02.125Z"},"accession":"S-EPMC12492265","cross_references":{"pubmed":["40971954"],"doi":["10.1093/gbe/evaf172"]}}