{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ogbuagu O"],"funding":["NIAID NIH HHS","Gilead Sciences Inc"],"pagination":["e397-e407"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12492902"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(7)"],"pubmed_abstract":["<h4>Background</h4>In DISCOVER, a multinational, randomised controlled trial, emtricitabine and tenofovir alafenamide compared with emtricitabine and tenofovir disoproxil fumarate showed non-inferior efficacy for HIV prevention and improved bone mineral density and renal safety biomarkers at week 48. We report outcomes analysed after all participants had completed 96 weeks of follow-up.<h4>Methods</h4>This study is an ongoing, randomised, double-blind, multicentre, active-controlled, phase 3, non-inferiority trial done at 94 community, public health, and hospital-associated clinics located in Europe and North America. Adult cisgender men and transgender women who have sex with men, both with a high risk of acquiring HIV as determined by self-reported sexual behaviour or recent sexually tra"],"journal":["The lancet. HIV"],"pubmed_title":["Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial."],"pmcid":["PMC12492902"],"funding_grant_id":["P30 AI050410"],"pubmed_authors":["Young B","Ebrahimi R","Taylor S","Haas B","Osiyemi O","Philibert P","Sinclair G","Coleman M","Hurt C","Hengel R","Kronborg G","Brainard DM","Krznaric I","Salazar L","Ogbuagu O","Mounzer K","Salazar LC","Burack J","Tremblay C","Gladstein J","Hosek S","Hassler S","Post F","Sobieszczyk M","Kegg S","Trottier B","Scarsella A","Nwokolo N","Hare C","Flamm J","Dinges W","Lazzarin A","Schembri G","Workowski K","Antinori A","Asmuth D","Shao Y","Brinson C","Brunetta JM","Larsen CS","Doblecki-Lewis S","Reeves I","Whitlock G","Spinner CD","Gilson R","Grossberg R","Henry W","Yawetz S","Ruane P","Ruane PJ","Cox S","Clarke A","Del Romero Guerrero J","Henry K","Petroll A","Richmond G","Podzamczer D","Rieger A","Stephens J","DISCOVER study team","Iandiorio M","Mills A","Voskuhl G","DeJesus E","Hardy WD","Phoenix J","Cua E","Carter C","Coll J","Benson P","Crespo Casal M","Brar I","Jessen H","Bergin C","Szabo J","Creticos C","Lucasti C","Markowitz M","Molina JM","Rashbaum B","Asmuth DM","Crofoot G","Wade B","Donovan T","Cespedes M","Daar E","Gerstoft J","Grant R","Mayer K","Shalit P","Spinner C","Leen C","Scott M","Avery A","Mannheimer S","de Wet J","Das M","Prins M","Morris S","Gallant J","LaMarca A","Ramgopal M","Wohl D","Apea V","Campbell T","Dosekun O","Cruickshank F","Mallon P","Pialoux G","Berhe M","Martorell C","Baeten JM","Hodge T","Kintu A","Thompson M","Knecht G","Halperin J","Brunetta J","Larsen OD"],"additional_accession":[]},"is_claimable":false,"name":"Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial.","description":"<h4>Background</h4>In DISCOVER, a multinational, randomised controlled trial, emtricitabine and tenofovir alafenamide compared with emtricitabine and tenofovir disoproxil fumarate showed non-inferior efficacy for HIV prevention and improved bone mineral density and renal safety biomarkers at week 48. We report outcomes analysed after all participants had completed 96 weeks of follow-up.<h4>Methods</h4>This study is an ongoing, randomised, double-blind, multicentre, active-controlled, phase 3, non-inferiority trial done at 94 community, public health, and hospital-associated clinics located in Europe and North America. Adult cisgender men and transgender women who have sex with men, both with a high risk of acquiring HIV as determined by self-reported sexual behaviour or recent sexually tra","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2026-06-04T06:54:24.733Z","creation":"2026-05-06T03:12:18.257Z"},"accession":"S-EPMC12492902","cross_references":{"pubmed":["34197772"],"doi":["10.1016/S2352-3018(21)00071-0","10.1016/s2352-3018(21)00071-0"]}}