{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Z"],"funding":["Noncommunicable Chronic Diseases-National Science and Technology Major Project","Scientific Innovation Project of Shanghai Education Committee","Shanghai Shenkang Hospital Development Center","National Natural Science Foundation of China","Shanghai Municipal Health Bureau"],"pagination":["238"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12492912"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["<h4>Background</h4>Resistance to poly (ADP-ribose) polymerase inhibitors (PARPi) poses a major challenge to therapeutic efficacy in castration-resistant prostate cancer (CRPC). Although circular RNAs (circRNAs) have emerged as critical regulators in cancer biology, their involvement in PARPi resistance remains largely uncharacterized.<h4>Objective</h4>This study aims to elucidate the molecular mechanism by which hsa_circ_0038737 modulates PARPi resistance in CRPC through post-transcriptional regulatory pathways.<h4>Methods</h4>We employed a comprehensive set of in vitro and in vivo approaches, including qRT-PCR, RNA sequencing, RNA-protein pull-down, RNA immunoprecipitation, functional assays, and xenograft/organoid models, to investigate the biological function and mechanistic role of hsa"],"journal":["Molecular cancer"],"pubmed_title":["Hsa_circ_0038737 promotes PARPi resistance in castration-resistant prostate cancer via IGF2BP3-mediated DNPH1 mRNA stabilization."],"pmcid":["PMC12492912"],"funding_grant_id":["82474506","2023ZD0510300","2021-01-07-00-07-E00080","SHDC2025CCS007","82403377","2020CXJQ03"],"pubmed_authors":["Anwaier A","Zhang Z","Tian X","Hong Z","Qin X","Ye D","Feng T","Liu S","Wang Z","Xu W","Ge Q"],"additional_accession":[]},"is_claimable":false,"name":"Hsa_circ_0038737 promotes PARPi resistance in castration-resistant prostate cancer via IGF2BP3-mediated DNPH1 mRNA stabilization.","description":"<h4>Background</h4>Resistance to poly (ADP-ribose) polymerase inhibitors (PARPi) poses a major challenge to therapeutic efficacy in castration-resistant prostate cancer (CRPC). Although circular RNAs (circRNAs) have emerged as critical regulators in cancer biology, their involvement in PARPi resistance remains largely uncharacterized.<h4>Objective</h4>This study aims to elucidate the molecular mechanism by which hsa_circ_0038737 modulates PARPi resistance in CRPC through post-transcriptional regulatory pathways.<h4>Methods</h4>We employed a comprehensive set of in vitro and in vivo approaches, including qRT-PCR, RNA sequencing, RNA-protein pull-down, RNA immunoprecipitation, functional assays, and xenograft/organoid models, to investigate the biological function and mechanistic role of hsa","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T02:00:53.222Z","creation":"2026-05-04T03:13:23.094Z"},"accession":"S-EPMC12492912","cross_references":{"pubmed":["41039575"],"doi":["10.1186/s12943-025-02447-y"]}}