biostudies-literatureUnknown6(1)Mizuki Y<h4>Objective</h4>To investigate seasonal trends in the onset of Vogt-Koyanagi-Harada (VKH) disease in Japan and evaluate the influence of the coronavirus disease 2019 (COVID-19) pandemic, including severe cases and vaccination campaigns, on disease onset.<h4>Design</h4>A retrospective cohort study using clinical records and public health data.<h4>Participants</h4>A total of 320 Japanese VKH patients with a known month of onset who were initially treated at Yokohama City University Hospital between April 2007 and March 2024.<h4>Methods</h4>The monthly distribution of VKH onset cases was assessed using the Roger test to determine seasonality before and after the COVID-19 pandemic. Severe COVID-19 case data (April 2020 to March 2024) were obtained from government sources. The COVID-19 vaccinOphthalmology science100902https://www.ebi.ac.uk/biostudies/studies/S-EPMC12494803biostudies-literatureSeasonal Variations of Vogt-Koyanagi-Harada Disease in Japan: A Study on Long-Term Trends and the Influence of Coronavirus Disease 2019 (COVID-19).PMC12494803Yamamoto KOhno SOkada HSakono TMizuki YHorita NKawagoe TMizuki NIshihara MYamada NMeguro AfalseSeasonal Variations of Vogt-Koyanagi-Harada Disease in Japan: A Study on Long-Term Trends and the Influence of Coronavirus Disease 2019 (COVID-19).<h4>Objective</h4>To investigate seasonal trends in the onset of Vogt-Koyanagi-Harada (VKH) disease in Japan and evaluate the influence of the coronavirus disease 2019 (COVID-19) pandemic, including severe cases and vaccination campaigns, on disease onset.<h4>Design</h4>A retrospective cohort study using clinical records and public health data.<h4>Participants</h4>A total of 320 Japanese VKH patients with a known month of onset who were initially treated at Yokohama City University Hospital between April 2007 and March 2024.<h4>Methods</h4>The monthly distribution of VKH onset cases was assessed using the Roger test to determine seasonality before and after the COVID-19 pandemic. Severe COVID-19 case data (April 2020 to March 2024) were obtained from government sources. The COVID-19 vaccin2026-01-01T00:00:00Z2026 Jan2026-06-15T06:09:36.821Z2026-06-15T03:08:42.698ZS-EPMC124948034104911410.1016/j.xops.2025.100902