{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jansson M"],"funding":["NIA NIH HHS"],"pagination":["46"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1249565"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6"],"pubmed_abstract":["<h4>Background</h4>The aim was to ascertain whether thrombocyte MAO (trbc-MAO) activity and depressed state are genetically associated with the MAO locus on chromosome X (Xp11.3 - 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in a Swedish sample (N = 573 individuals).<h4>Results</h4>Our results reveal a profound SNP desert in the MAOB gene. Both the MAOA and MAOB genes segregate as two distinct LD blocks. We found a significant association between two MAOA gene haplotypes and reduced trbc-MAO activity, but no association with depressed state.<h4>Conclusion</h4>The MAO locus seems to have an effect on trbc-MAO activity in the study population. The findings suggest incomplete X-"],"journal":["BMC genetics"],"pubmed_title":["MAOA haplotypes associated with thrombocyte-MAO activity."],"pmcid":["PMC1249565"],"funding_grant_id":["AG 04563","AG 10175","R01 AG010175"],"pubmed_authors":["Schalling M","Oreland L","Pedersen NL","Dickman P","Andersson B","Sullivan PF","Jansson M","McCarthy S"],"additional_accession":[]},"is_claimable":false,"name":"MAOA haplotypes associated with thrombocyte-MAO activity.","description":"<h4>Background</h4>The aim was to ascertain whether thrombocyte MAO (trbc-MAO) activity and depressed state are genetically associated with the MAO locus on chromosome X (Xp11.3 - 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in a Swedish sample (N = 573 individuals).<h4>Results</h4>Our results reveal a profound SNP desert in the MAOB gene. Both the MAOA and MAOB genes segregate as two distinct LD blocks. We found a significant association between two MAOA gene haplotypes and reduced trbc-MAO activity, but no association with depressed state.<h4>Conclusion</h4>The MAO locus seems to have an effect on trbc-MAO activity in the study population. The findings suggest incomplete X-","dates":{"release":"2005-01-01T00:00:00Z","publication":"2005 Sep","modification":"2025-04-22T17:09:41.31Z","creation":"2019-03-27T01:25:19Z"},"accession":"S-EPMC1249565","cross_references":{"pubmed":["16174289"],"doi":["10.1186/1471-2156-6-46"]}}