biostudies-literatureJansson MNIA NIH HHS46https://www.ebi.ac.uk/biostudies/studies/S-EPMC1249565biostudies-literatureUnknown6<h4>Background</h4>The aim was to ascertain whether thrombocyte MAO (trbc-MAO) activity and depressed state are genetically associated with the MAO locus on chromosome X (Xp11.3 - 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in a Swedish sample (N = 573 individuals).<h4>Results</h4>Our results reveal a profound SNP desert in the MAOB gene. Both the MAOA and MAOB genes segregate as two distinct LD blocks. We found a significant association between two MAOA gene haplotypes and reduced trbc-MAO activity, but no association with depressed state.<h4>Conclusion</h4>The MAO locus seems to have an effect on trbc-MAO activity in the study population. The findings suggest incomplete X-BMC geneticsMAOA haplotypes associated with thrombocyte-MAO activity.PMC1249565AG 04563AG 10175R01 AG010175Schalling MOreland LPedersen NLDickman PAndersson BSullivan PFJansson MMcCarthy SfalseMAOA haplotypes associated with thrombocyte-MAO activity.<h4>Background</h4>The aim was to ascertain whether thrombocyte MAO (trbc-MAO) activity and depressed state are genetically associated with the MAO locus on chromosome X (Xp11.3 - 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in a Swedish sample (N = 573 individuals).<h4>Results</h4>Our results reveal a profound SNP desert in the MAOB gene. Both the MAOA and MAOB genes segregate as two distinct LD blocks. We found a significant association between two MAOA gene haplotypes and reduced trbc-MAO activity, but no association with depressed state.<h4>Conclusion</h4>The MAO locus seems to have an effect on trbc-MAO activity in the study population. The findings suggest incomplete X-2005-01-01T00:00:00Z2005 Sep2025-04-22T17:09:41.31Z2019-03-27T01:25:19ZS-EPMC12495651617428910.1186/1471-2156-6-46