{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luo D"],"funding":["China-Japan Friendship Hospital"],"pagination":["437"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12495665"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["<h4>Background</h4>Accurate preoperative identification of high-risk pathological features in early-stage lung adenocarcinoma is critical for guiding surgical decisions and improving patient outcomes. This study aimed to develop and validate a nomogram to predict high-risk pathology in clinical stage IA lung adenocarcinoma located in the left upper lobe (LUL), an anatomical site with distinct surgical implications.<h4>Methods</h4>We retrospectively reviewed 545 patients with clinical stage IA LUL adenocarcinoma who underwent surgery between January 2018 and May 2022. The cohort was randomly divided into training (80%) and validation (20%) sets. Independent predictors were identified via multivariate logistic regression and further validated using LASSO regression. A nomogram was constructe"],"journal":["BMC surgery"],"pubmed_title":["Development and validation of a nomogram for predicting high-risk pathology in clinical stage lA left upper lobe lung adenocarcinoma."],"pmcid":["PMC12495665"],"funding_grant_id":["ZRJY2023-QM34"],"pubmed_authors":["Liang C","Feng H","Yu Q","Su K","Han Y","Zhu W","Luo D"],"additional_accession":[]},"is_claimable":false,"name":"Development and validation of a nomogram for predicting high-risk pathology in clinical stage lA left upper lobe lung adenocarcinoma.","description":"<h4>Background</h4>Accurate preoperative identification of high-risk pathological features in early-stage lung adenocarcinoma is critical for guiding surgical decisions and improving patient outcomes. This study aimed to develop and validate a nomogram to predict high-risk pathology in clinical stage IA lung adenocarcinoma located in the left upper lobe (LUL), an anatomical site with distinct surgical implications.<h4>Methods</h4>We retrospectively reviewed 545 patients with clinical stage IA LUL adenocarcinoma who underwent surgery between January 2018 and May 2022. The cohort was randomly divided into training (80%) and validation (20%) sets. Independent predictors were identified via multivariate logistic regression and further validated using LASSO regression. A nomogram was constructe","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-06T13:38:36.518Z","creation":"2026-05-31T03:08:07.016Z"},"accession":"S-EPMC12495665","cross_references":{"pubmed":["41044503"],"doi":["10.1186/s12893-025-03149-4"]}}