biostudies-literatureUnknown48(10)Takase MFamily history of hypertension may reflect genetic and lifestyle factors. Genetic risk can be assessed using polygenic risk score (PRS); however, whether PRS can stratify hypertension risk when combined with family history and lifestyle information is unclear. This prospective cohort study included 9,001 hypertension-free individuals aged ≥20 years from the Tohoku Medical Megabank Community-Based Cohort Study. Participants were scored on lifestyle factors, including body mass index, urinary sodium-to-potassium ratio, physical activity, alcohol consumption, and smoking at recruitment. During the mean follow-up of 4.3 years, 2822 (31.4%) cases of hypertension occurred. High genetic risk and poor lifestyle were associated with increased hypertension risk. Compared with participants with low gHypertension research : official journal of the Japanese Society of Hypertension2606-2617https://www.ebi.ac.uk/biostudies/studies/S-EPMC12497643biostudies-literatureAssociations of family history of hypertension, genetic, and lifestyle risks with incident hypertension.PMC12497643Chiba IKodama ENNarita AKobayashi TOgishima STamiya GOrui MNochioka KIshikuro MSatoh MTokioka SKuriyama SHatanaka RHozawa ATakahashi IHamanaka YNagaie STakase MNakaya NNakaya KObara TYamamoto MTsuchiya NToMMo investigatorsKogure MHirata TMetoki HOhseto HFuse NSugawara JNakamura TfalseAssociations of family history of hypertension, genetic, and lifestyle risks with incident hypertension.Family history of hypertension may reflect genetic and lifestyle factors. Genetic risk can be assessed using polygenic risk score (PRS); however, whether PRS can stratify hypertension risk when combined with family history and lifestyle information is unclear. This prospective cohort study included 9,001 hypertension-free individuals aged ≥20 years from the Tohoku Medical Megabank Community-Based Cohort Study. Participants were scored on lifestyle factors, including body mass index, urinary sodium-to-potassium ratio, physical activity, alcohol consumption, and smoking at recruitment. During the mean follow-up of 4.3 years, 2822 (31.4%) cases of hypertension occurred. High genetic risk and poor lifestyle were associated with increased hypertension risk. Compared with participants with low g2025-01-01T00:00:00Z2025 Oct2026-06-04T04:47:49.355Z2026-05-05T03:12:32.323ZS-EPMC124976434080416410.1038/s41440-025-02314-9