{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19"],"submitter":["Do Lan H"],"pubmed_abstract":["<h4>Background</h4>Vietnam is an endemic region for nasopharyngeal cancer (NPC), with approximately 70% of cases diagnosed at stage III-IVa and 90% presenting with undifferentiated histology closely related to Epstein-Barr virus (EBV) infection. However, no studies have identified biomarkers predictive of recurrence and metastasis. This study aimed to determine the cut-off concentrations of cell-free (cf) EBV DNA for predicting recurrence and metastasis in NPC.<h4>Methods</h4>A longitudinal descriptive study was conducted on 58 patients with stage III-IVa undifferentiated NPC between August 2021 and August 2024. We analysed the predictive value of cf EBV DNA concentrations at pre-treatment (preEBV) and post-treatment (postEBV, 6 months postEBV [EBV6], 12 months postEBV [EBV12]) in relation"],"journal":["Clinical Medicine Insights. Oncology"],"pagination":["11795549251375893"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12497975"],"repository":["biostudies-literature"],"pubmed_title":["Predictive Value of Plasma Epstein-Barr Virus DNA Concentration for Recurrence and Metastasis in Advanced-Stage Nasopharyngeal Carcinoma: A Longitudinal, Descriptive Investigation."],"pmcid":["PMC12497975"],"pubmed_authors":["Nghiem Duc T","Tien Nguyen S","Do Lan H","Nguyen Van D","Dinh Le T","Van Nguyen B","Nguyen Van B","Thanh Quan N"],"additional_accession":[]},"is_claimable":false,"name":"Predictive Value of Plasma Epstein-Barr Virus DNA Concentration for Recurrence and Metastasis in Advanced-Stage Nasopharyngeal Carcinoma: A Longitudinal, Descriptive Investigation.","description":"<h4>Background</h4>Vietnam is an endemic region for nasopharyngeal cancer (NPC), with approximately 70% of cases diagnosed at stage III-IVa and 90% presenting with undifferentiated histology closely related to Epstein-Barr virus (EBV) infection. However, no studies have identified biomarkers predictive of recurrence and metastasis. This study aimed to determine the cut-off concentrations of cell-free (cf) EBV DNA for predicting recurrence and metastasis in NPC.<h4>Methods</h4>A longitudinal descriptive study was conducted on 58 patients with stage III-IVa undifferentiated NPC between August 2021 and August 2024. We analysed the predictive value of cf EBV DNA concentrations at pre-treatment (preEBV) and post-treatment (postEBV, 6 months postEBV [EBV6], 12 months postEBV [EBV12]) in relation","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-04T06:58:06.94Z","creation":"2026-05-06T03:12:33.276Z"},"accession":"S-EPMC12497975","cross_references":{"pubmed":["41059139"],"doi":["10.1177/11795549251375893"]}}