{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Padra M"],"funding":["the Royal Physiographic Society of Lund","the Alfred Österlund Foundation","the Swedish Government Funds for Clinical Research","the Swedish Research Council","the Swedish Heart and Lung Foundation"],"pagination":["612-622"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12498364"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["73(4)"],"pubmed_abstract":["Allergic asthma is characterized by Type 2 inflammation and eosinophilia. Tartrate-resistant acid phosphatase 5 (TRAP5; also referred to as acid phosphatase 5 [ACP5]) is a metallophosphatase expressed by alveolar macrophages that dephosphorylates osteopontin, a phosphoglycoprotein with increased expression in asthma. To investigate the role of TRAP5 during asthma, we used a murine model of ovalbumin (OVA)-induced allergic airway inflammation as well as IL-33-induced airway inflammation, including <i>Trap</i>5<sup>-/-</sup> and wild-type (WT) mice. Histological analyses of murine lung revealed that OVA-induced inflammation induced the formation of inflammatory lesions and increased mucus production in both WT and <i>Trap</i>5<sup>-/-</sup> mice. However, lower cytokine levels (including IL-"],"journal":["American journal of respiratory cell and molecular biology"],"pubmed_title":["Tartrate-Resistant Acid Phosphatase 5 (TRAP5) Promotes Eosinophil Migration During Allergic Asthma."],"pmcid":["PMC12498364"],"funding_grant_id":["46402","20220193","2023-02013"],"pubmed_authors":["Padra M","Egesten A","Marcoux G","Bhongir RKV","Bergwik J","Papareddy P","Adler A"],"additional_accession":[]},"is_claimable":false,"name":"Tartrate-Resistant Acid Phosphatase 5 (TRAP5) Promotes Eosinophil Migration During Allergic Asthma.","description":"Allergic asthma is characterized by Type 2 inflammation and eosinophilia. Tartrate-resistant acid phosphatase 5 (TRAP5; also referred to as acid phosphatase 5 [ACP5]) is a metallophosphatase expressed by alveolar macrophages that dephosphorylates osteopontin, a phosphoglycoprotein with increased expression in asthma. To investigate the role of TRAP5 during asthma, we used a murine model of ovalbumin (OVA)-induced allergic airway inflammation as well as IL-33-induced airway inflammation, including <i>Trap</i>5<sup>-/-</sup> and wild-type (WT) mice. Histological analyses of murine lung revealed that OVA-induced inflammation induced the formation of inflammatory lesions and increased mucus production in both WT and <i>Trap</i>5<sup>-/-</sup> mice. However, lower cytokine levels (including IL-","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T04:50:04.358Z","creation":"2026-05-05T03:12:43.783Z"},"accession":"S-EPMC12498364","cross_references":{"pubmed":["40173299"],"doi":["10.1165/rcmb.2024-0304OC"]}}