biostudies-literaturePadra Mthe Royal Physiographic Society of Lundthe Alfred Österlund Foundationthe Swedish Government Funds for Clinical Researchthe Swedish Research Councilthe Swedish Heart and Lung Foundation612-622https://www.ebi.ac.uk/biostudies/studies/S-EPMC12498364biostudies-literatureUnknown73(4)Allergic asthma is characterized by Type 2 inflammation and eosinophilia. Tartrate-resistant acid phosphatase 5 (TRAP5; also referred to as acid phosphatase 5 [ACP5]) is a metallophosphatase expressed by alveolar macrophages that dephosphorylates osteopontin, a phosphoglycoprotein with increased expression in asthma. To investigate the role of TRAP5 during asthma, we used a murine model of ovalbumin (OVA)-induced allergic airway inflammation as well as IL-33-induced airway inflammation, including <i>Trap</i>5^-/- and wild-type (WT) mice. Histological analyses of murine lung revealed that OVA-induced inflammation induced the formation of inflammatory lesions and increased mucus production in both WT and <i>Trap</i>5^-/- mice. However, lower cytokine levels (including IL-American journal of respiratory cell and molecular biologyTartrate-Resistant Acid Phosphatase 5 (TRAP5) Promotes Eosinophil Migration During Allergic Asthma.PMC1249836446402202201932023-02013Padra MEgesten AMarcoux GBhongir RKVBergwik JPapareddy PAdler AfalseTartrate-Resistant Acid Phosphatase 5 (TRAP5) Promotes Eosinophil Migration During Allergic Asthma.Allergic asthma is characterized by Type 2 inflammation and eosinophilia. Tartrate-resistant acid phosphatase 5 (TRAP5; also referred to as acid phosphatase 5 [ACP5]) is a metallophosphatase expressed by alveolar macrophages that dephosphorylates osteopontin, a phosphoglycoprotein with increased expression in asthma. To investigate the role of TRAP5 during asthma, we used a murine model of ovalbumin (OVA)-induced allergic airway inflammation as well as IL-33-induced airway inflammation, including <i>Trap</i>5^-/- and wild-type (WT) mice. Histological analyses of murine lung revealed that OVA-induced inflammation induced the formation of inflammatory lesions and increased mucus production in both WT and <i>Trap</i>5^-/- mice. However, lower cytokine levels (including IL-2025-01-01T00:00:00Z2025 Oct2026-06-04T04:50:04.358Z2026-05-05T03:12:43.783ZS-EPMC124983644017329910.1165/rcmb.2024-0304OC