biostudies-literatureGiacobbe DRPfizer Global Medical Grantsdlaf177https://www.ebi.ac.uk/biostudies/studies/S-EPMC12498522biostudies-literatureUnknown7(5)<h4>Objectives</h4>In this multicentre, prospective study, we aimed to describe the use of isavuconazole in critically ill adult patients in ICU, in terms of patient characteristics, infection characteristics and outcomes.<h4>Methods</h4>Prospective, observational study of ICU patients treated with isavuconazole from January 2023 to 30 April 2025 in 17 centres (ISA-SITA study within the MULTI-SITA project).<h4>Results</h4>A total of 177 ICU patients treated with isavuconazole were included in the study. Most patients showed at least one European Organisation for Research and Treatment of Cancer/Mycoses Study Group Education and Research Consortium (EORTC/MSGERC) or FUNgal Diseases in adult patients in Intensive Care Unit (FUNDICU) host factor (141/177, 79.7%). Overall, 82/177 patients (46.JAC-antimicrobial resistanceUse of isavuconazole in critically ill patients in intensive care units: a prospective, observational, multicentre, cohort study.PMC1249852273582567De Benedetto IMarchese AAlbertini MAngelini JRinaldi MGiuliano SPallone RCacopardo BBattaglini DCaroli ARusso ALivanu DCostarella DPiana MCasarini MSerapide FBruni APinna SMDe Pascale GBassetti MMerli MRicciardetto MSimoncini EGiacobbe DRPortunato FDe Rosa FGMengato DFanelli CFranzo ADi Pilato VDel Bono VGiannella MAldieri CMoreal CPontali EDel Puente FDi Meco GGallone SViale PChemello DNavalesi PBriano FDi Biagio AGarofalo ESantoro ATiberio ICappello ABavastro MFava FLonghini FMarino AMuccio MBono ERobba CTorti CLosito ARShbaklo NMartini LPatroniti NGullotta CBartalucci CGiacomini MFlammini SMurgia YCampanella EAPanese SCammarota FBall LD'amico FMaida IAntola SMunari MGuastavino SAsperges EMazzitelli MLamarina AFranceschini EMagnasco LSanguinetti MBlasi Vacca ETravi GGeremia NCoppo ECattelan AMeschiari MISA-SITA investigatorsMusso SCosentino FFerin SBoffa NMora SScaglione VVena AMontanari LMikulska MViglietti GSchiavoni RLupia TRosso NBoni SMeloni MCCalabresi ACampi COltolini CSignori ASerino FSMomesso ESassi SCorcione STigano SfalseUse of isavuconazole in critically ill patients in intensive care units: a prospective, observational, multicentre, cohort study.<h4>Objectives</h4>In this multicentre, prospective study, we aimed to describe the use of isavuconazole in critically ill adult patients in ICU, in terms of patient characteristics, infection characteristics and outcomes.<h4>Methods</h4>Prospective, observational study of ICU patients treated with isavuconazole from January 2023 to 30 April 2025 in 17 centres (ISA-SITA study within the MULTI-SITA project).<h4>Results</h4>A total of 177 ICU patients treated with isavuconazole were included in the study. Most patients showed at least one European Organisation for Research and Treatment of Cancer/Mycoses Study Group Education and Research Consortium (EORTC/MSGERC) or FUNgal Diseases in adult patients in Intensive Care Unit (FUNDICU) host factor (141/177, 79.7%). Overall, 82/177 patients (46.2025-01-01T00:00:00Z2025 Oct2026-06-04T06:55:31.649Z2026-05-06T03:12:39.591ZS-EPMC124985224105926710.1093/jacamr/dlaf177