{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Y"],"funding":["Shanghai's Science and Technology Innovation Action Plan International Science and Technology Cooperation Project","Shanghai Municipal Health Commission Research Project Fund"],"pagination":["e01104"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12499386"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(37)"],"pubmed_abstract":["Fatal jellyfish stings often cause multi-organ failure. Until now, these fatal outcomes are attributed to the direct toxic effects of the venom. Here, a mouse model of delayed jellyfish envenomation syndrome (DJES) is established and showed that venom from Nemopilema nomurai jellyfish can trigger a deadly cytokine storm - a severe inflammatory reaction. Mice injected with the venom displayed acute multi-organ failure and significant upregulation of over 20 pro-inflammatory cytokines (including IL-6, TNF-α, CXCL2, and CCL4) in the heart, liver, and kidneys. Transcriptomic analyses identified NF-κB p65 subunit activation as central to the cytokine storm induction. Knockdown of p65 in macrophages reduced cytokine production and improved cell viability. Treatment with dexamethasone, an NF-κB i"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Cytokine Storm Induction Linked to Multi-Organ Failure in Fatal Jellyfish Stings."],"pmcid":["PMC12499386"],"funding_grant_id":["202240144","24410710100"],"pubmed_authors":["Chen J","Geng X","Zhang J","Chen L","Hou X","Yang F","Lv J","Xiao L","Sun Q","Lin H","Liu C","Yan B","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Cytokine Storm Induction Linked to Multi-Organ Failure in Fatal Jellyfish Stings.","description":"Fatal jellyfish stings often cause multi-organ failure. Until now, these fatal outcomes are attributed to the direct toxic effects of the venom. Here, a mouse model of delayed jellyfish envenomation syndrome (DJES) is established and showed that venom from Nemopilema nomurai jellyfish can trigger a deadly cytokine storm - a severe inflammatory reaction. Mice injected with the venom displayed acute multi-organ failure and significant upregulation of over 20 pro-inflammatory cytokines (including IL-6, TNF-α, CXCL2, and CCL4) in the heart, liver, and kidneys. Transcriptomic analyses identified NF-κB p65 subunit activation as central to the cytokine storm induction. Knockdown of p65 in macrophages reduced cytokine production and improved cell viability. Treatment with dexamethasone, an NF-κB i","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T04:43:33.72Z","creation":"2026-05-05T03:12:21.621Z"},"accession":"S-EPMC12499386","cross_references":{"pubmed":["40653782"],"doi":["10.1002/advs.202501104"]}}