{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang T"],"funding":["National Key R&D Program of China","111 Project","Priority Academic Program Development of Jiangsu Higher Education Institutions","National Natural Science Foundation of China","Higher Education Discipline Innovation Project","National Key Research and Development Program of China"],"pagination":["e02793"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12499425"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(37)"],"pubmed_abstract":["Cadmium (Cd) exposure is strongly linked to various diseases and dysregulation of autophagy is a pivotal mechanism in Cd toxicity. Targeted autophagy strategies are promising for the treatment of autophagy dysregulation-related diseases, including Cd poisoning. However, the current understanding of autophagy mechanisms remains limited, hindering the development of effective strategies. Herein, a novel autophagy pathway, transcellular autophagy. Cd triggers this process in hepatocytes, facilitating the transfer of autophagosomes from damaged to healthy cells for degradation. Mechanistically, reactive oxygen species accumulation is a key driver of transcellular autophagy activation, while the disruption of autophagy fusion mechanisms triggers its activation. Notably, Cd-induced transcellular"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Tunneling Nanotube-Mediated Transcellular Autophagy Alleviates Cadmium Induced Hepatocyte Injury."],"pmcid":["PMC12499425"],"funding_grant_id":["32072923","32072933","D18007","32273086","2023YFD1801100","32102732"],"pubmed_authors":["Zou H","Ma Y","Tong X","Bian J","Wang L","Liu Z","Ali W","Zhu J","Song R","Wang T","Chen Y","Gu J","Sun J","Yuan Y"],"additional_accession":[]},"is_claimable":false,"name":"Tunneling Nanotube-Mediated Transcellular Autophagy Alleviates Cadmium Induced Hepatocyte Injury.","description":"Cadmium (Cd) exposure is strongly linked to various diseases and dysregulation of autophagy is a pivotal mechanism in Cd toxicity. Targeted autophagy strategies are promising for the treatment of autophagy dysregulation-related diseases, including Cd poisoning. However, the current understanding of autophagy mechanisms remains limited, hindering the development of effective strategies. Herein, a novel autophagy pathway, transcellular autophagy. Cd triggers this process in hepatocytes, facilitating the transfer of autophagosomes from damaged to healthy cells for degradation. Mechanistically, reactive oxygen species accumulation is a key driver of transcellular autophagy activation, while the disruption of autophagy fusion mechanisms triggers its activation. Notably, Cd-induced transcellular","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-04T04:45:10.24Z","creation":"2026-05-05T03:12:29.735Z"},"accession":"S-EPMC12499425","cross_references":{"pubmed":["40719264"],"doi":["10.1002/advs.202502793"]}}