{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["122(11)"],"submitter":["Volkmar M"],"funding":["This study was prepared within the project \"GreenProScale-Process integration and scale-up of a biorefinery for green waste, taking into account the robustness of the system\" from the innovation area \"BioBall,\" which is funded by the German Federal Ministry of Education and Research (BMBF, grant numbers 031B1497A and 031B1497B). The laboratory of L.M.B. is partially funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy-Exzellenzcluster 2186 \"FSC-The Fuel Science Center\" DFG ID: 390919832."],"pubmed_abstract":["Itaconic acid is a monomer for high performance polymers. While produced in industry with the filamentous fungi Aspergillus terreus, the production with the smut fungus Ustilago maydis was proposed recently. The strict aerobic process suffers from high power input via gassing and stirring. Here, we investigated in detail possible scenarios for the reduction of energy use during cultivation. In contrast to fermentations with other organic acids, in which even small oxygen concentrations in the medium hinders production, low oxygen availability correlated with increased itaconic acid titer and yield. This is somewhat surprising, as not only the sensitivity of itaconic acid producing U. maydis to oxygen deprivation was previously reported, but also the lower degree of reduction compared to gl"],"journal":["Biotechnology and bioengineering"],"pagination":["3007-3017"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12503012"],"repository":["biostudies-literature"],"pubmed_title":["Low Oxygen Availability Increases Itaconate Production by Ustilago maydis."],"pmcid":["PMC12503012"],"pubmed_authors":["Schonrock S","Volkmar M","Holtmann D","Erdmann N","Fuderer E","Ulber R","Bartzack F","Laudensack W","Blank LM"],"additional_accession":[]},"is_claimable":false,"name":"Low Oxygen Availability Increases Itaconate Production by Ustilago maydis.","description":"Itaconic acid is a monomer for high performance polymers. While produced in industry with the filamentous fungi Aspergillus terreus, the production with the smut fungus Ustilago maydis was proposed recently. The strict aerobic process suffers from high power input via gassing and stirring. Here, we investigated in detail possible scenarios for the reduction of energy use during cultivation. In contrast to fermentations with other organic acids, in which even small oxygen concentrations in the medium hinders production, low oxygen availability correlated with increased itaconic acid titer and yield. This is somewhat surprising, as not only the sensitivity of itaconic acid producing U. maydis to oxygen deprivation was previously reported, but also the lower degree of reduction compared to gl","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-04T06:27:17.541Z","creation":"2026-05-06T03:13:11.489Z"},"accession":"S-EPMC12503012","cross_references":{"pubmed":["40751411"],"doi":["10.1002/bit.70035"]}}